Manufacturing Technologist

Position Title:

Manufacturing Technologist (2 openings)

Associate Director, Drug Development & Production

CNSide Diagnostics, LLC, a subsidiary of Plus Therapeutics, Inc., develops and commercializes proprietary clinical diagnostic laboratory tests, such as CNSide, designed to identify tumor cells that have metastasized to the central nervous system in patients with carcinomas and melanomas. The CNSide Cerebrospinal Fluid Assay Platform enables quantitative analysis and molecular characterization of tumor cells and circulating tumor DNA in cerebrospinal fluid, informing and improving the clinical management of patients.

The Company is in the early stages of commercializing CNSide in the U.S.

We are seeking multiple Manufacturing Technologists to support internal manufacturing of assay‑critical consumables, including reagents, microfluidic chips, and preservation tubes. This hands‑on role is responsible for batch manufacturing, in‑process quality control, and documentation in a regulated laboratory environment.

These positions are critical to ensuring operational continuity, lot‑to‑lot consistency, and commercial readiness and are based at our Houston, TX, facility.

• Prepare antibody capture mixes, staining reagents, wash buffers, preservatives, and assay solutions.
• Execute manufacturing activities per SOPs and controlled batch records (electronic or paper).
• Perform in‑process QC testing, including concentration, pH, stability, and performance checks.
• Conduct lot‑to‑lot consistency testing.
• Clean, inspect, assemble, and QC microfluidic chips per internal specifications.
• Validate chip channels, alignment, and fluidics performance.
• Prepare and assemble Cee‑Sure® preservation tubes under appropriate environmental controls.
• Perform visual inspection, fill verification, and traceability documentation.
• Maintain complete, accurate, and audit‑ready batch records.
• Execute in‑process and final quality control steps.
• Support deviation investigations and corrective actions as needed.
• Track raw materials, component usage, and finished goods inventory.
• Support manufacturing scale‑up, qualification runs, and process validation.
• Partner with R&D to incorporate process improvements into production workflows.

• Bachelor’s degree in biology, Chemistry, Biochemistry, Biotechnology, or a related field.
• Hands‑on wet lab experience (pipetting, sterile technique, QC assays).
• Experience preparing biological reagents or buffer systems.
• Familiarity with batch manufacturing documentation and traceability.
• Experience in diagnostics, microfluidics, or regulated lab environments preferred.

• Ability to work in a regulated laboratory or manufacturing environment.
• Strong attention to detail and documentation accuracy.
• Comfortable working in controlled or cleanroom environments as required.
• Ability to manage multiple priorities in a fast‑paced, early‑stage company.
• Strong communication skills and ability to work cross‑functionally.

Plus Therapeutics, Inc. and CNSide Diagnostics, LLC are Equal Employment Opportunity employers and consider all qualified applicants without regard to any protected status.