Postdoctoral Fellow - Thoracic Head & Neck Medical Oncology

Requisition #:600657-

Department:
Thoracic H&N Med Onc-Rsch

Location:

Houston, TX

Posted Date:6/9/2025

Postdoctoral positions are available to study molecular mechanisms associated with therapeutic response and resistance to RAS inhibition in non-small cell lung cancer (NSCLC) in the laboratory of Ferdinandos Skoulidis, MD, PhD, at the University of Texas MD Anderson Cancer Center in Houston, TX. The lab is largely interested in understanding the molecular diversity of KRAS-mutant NSCLC and developing rational and tailored treatment strategies for patients bearing KRAS-mutant lung tumors.

We utilize a multifaceted approach that encompasses preclinical studies in immunocompetent syngeneic and genetically engineered co‑mutational models of KRAS‑mutant NSCLC as well as PDX/CDXs, in vitro models, and large collections of well‑annotated clinical specimens. We employ state‑of‑the‑art computational biology/bioinformatics approaches to dissect acute and adaptive responses to RAS inhibition in vitro and in vivo. We are committed to a question‑driven approach that seeks to address the most urgent clinically relevant scientific questions.

Applicants with experience in any of these areas and a true passion for cutting‑edge bench‑to‑bedside research are encouraged to apply and provide three professional references.

Trainees will perform basic and translational research involving molecular biology approaches (such as CRISPR/Cas technology, Western blotting, ELISA, immunohistochemistry), in vitro assays (such as drug screening, flow cytometry, development of resistant cell lines) and in vivo experiments using xenograft, syngeneic and genetically engineered mouse models of KRAS‑mutant lung cancer. Candidates with prior experience in computational biology will acquire additional skills and be involved in the analysis of single‑cell RNA Sequencing, WES, and in situ transcriptomics data.

Trainees will present their findings at regular lab meetings, departmental seminars, and national conferences. Trainees will submit their findings for publication in a peer‑reviewed scientific journal.

All duties and responsibilities are carried out in compliance with institutional policies, ethical research standards, and applicable federal and state regulations.

Applications are invited from qualified individuals interested in working in a translational research lab, with a PhD and/or MD. The ideal candidate(s) should have less than 2 years of prior postdoctoral experience and have a background in cancer or cell and molecular biology. Experience in RAS signaling and targeting, and studies involving mouse models of KRAS‑driven cancers is preferred. We are also looking for applicants with prior expertise in computational biology and bioinformatics, including analysis of single‑cell RNA sequencing data and in situ transcriptomics.

Candidates should be innovative thinkers and highly motivated to pursue an independent career in biomedical research.

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MD Anderson offers full‑time postdoc positions with a salary ranging from $64,000 to $76,000, depending on the number of years of postgraduate experience. The University of Texas MD Anderson Cancer Center offers excellent benefits, including medical, dental, paid time off, retirement,…