Research Associate - Medicinal Chemistry

Summary

The Erwin Lab at Baylor College of Medicine seeks a Research Associate to support the design, synthesis and characterization of novel ligands for treating repeat expansion disease research. Working under the general direction of the PI, this position assists with the synthesis of pyrrole‑imidazole polyamides and conjugates. The ideal candidate will have experience in multi‑step organic synthesis and a passion for translating chemical innovations into therapeutic leads.

• Conducts research experiments involving the synthesis of small molecule ligands that can be conjugated with pyrrole‑imidazole polyamides for therapeutic applications.
• Performs multi‑step syntheses of pyrrole‑imidazole polyamides via manual solid‑phase synthesis using Fmoc‑ and Boc‑protected amino acids.
• Conjugates polyamides to small molecules using standard coupling chemistry with various linker designs.
• Purifies compounds by reverse‑phase HPLC and conducts basic characterization using NMR and MALDI‑TOF mass spectrometry.
• Maintains detailed laboratory notebooks and presents findings at lab meetings.
• Conducts literature searches to support ongoing projects and compiles information in formats requested by the PI.
• Assists in optimizing linker chemistries and conjugation strategies under PI guidance.
• Prepares fluorescently labeled analogs following established protocols for uptake studies.
• Participates in troubleshooting and improving synthetic routes, escalating complex challenges to senior lab members.
• Maintains an accurate chemical inventory, supports purchasing needs, and helps ensure compliance with laboratory safety expectations.
• Performs other job related duties as assigned.

• Master's degree in Basic Science or a related field. Experience in lieu of degree will not be accepted.
• Three years of relevant experience typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.

• Experience with organic synthesis, peptide or oligomer assembly, or heterocyclic chemistry.
• Familiarity with HPLC purification, NMR sample preparation, and mass spectrometry.
• Strong organizational skills, attention to detail, and the ability to follow complex protocols.
• Demonstrated ability to work collaboratively in a research laboratory.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.