Postdoctoral Research Associate

Job Title

Postdoctoral Research Associate

Agency

Texas A&M University Health Science Center

Department

Ibt - Cedp - Dashwood

Proposed Minimum Salary

$5,084.00 monthly

Job Location

Houston, Texas

Job Type

Staff

Job Description

Our Commitment

Texas A&M University is committed to enriching the learning and working environment by promoting a culture that respects all perspectives, talents & lived experiences. Embracing varying opinions and perspectives strengthens our core values which are:
Respect, Excellence, Leadership, Loyalty, Integrity, and Selfless Service.

Who we are

As one of the fastest-growing academic health centers in the nation, Texas A&M Health encompasses five colleges and numerous centers and institutes working together to improve health through transformative education, innovative research and team-based health care delivery.

What we want

The Postdoctoral Research Associate will be involved in the identification of epigenetic and immunoepigenetic combination treatments that upregulate the MHC-I and MHC-II dependent genes to enhance host immune surveillance and anticancer efficacy. The position will support translational cancer prevention studies using cell-based systems, primary cultures, 3D spheroid/organoid models, molecular assays, immunological assays, and rodent tumor models

What you need to know

Salary:
Will be commensurate based on the selected hire's education and experience.

Location/

Schedule:

Houston, TX/Full-Time

Apply! Submitting a cover letter, CV/Resume to assist us with the review process. You may upload these documents on the application under CV/Resume.

Required

Education and Experience

* MD/PhD in biochemistry, cell biology, immunology, cancer biology, pharmacology, molecular biology, or a related biomedical science field.

Preferred Qualifications

* Experience with cancer biology, molecular biology, cell culture, and animal cancer models.

* MD/PhD with experience in translational cancer biology, cancer prevention, immunology, epigenetics, or related biomedical research. Animal cancer models, primary tissue culture, 3D spheroid/organoid cultures, molecular biology, protein biochemistry, and immunology assays.

* Epigenetics, HDAC biology, host immune surveillance, antigen-presentation pathways, immunoproteosome assays, with technical expertise of FACS, RNA-seq, Co-IP, ChIP, and T-cell co-culture systems.

* Experience in performing rodent tumor studies under approved IACUC protocols, including oral gavage, intra-venous, intra-peritoneal and subcutaneous injections

* Experience with antibody development, hybridoma screening, ELISA-based assays, and antibody characterization.

* Clinical or translational research background, including MD training or experience connecting preclinical findings to human disease relevance, is preferred.

Knowledge, Skills, and Abilities

* Ability to multi-task and work cooperatively with others.

* Must be literate in the English language and be able to comprehend and follow effectively both written and verbal instructions.

* Excellent interpersonal, oral and written communication skills in English.

* Ability to do independent research in areas related to cancer immunology and epigenetics.

* Ability to maintain accurate records, analyze data, prepare figures and reports, and contribute to manuscripts and presentations.

Responsibilities

Transcriptional and epigenetic regulation of MHC

* Identification of epigenetic and immunoepigenetic combination treatments that upregulate MHC-I and MHC-II dependent genes to enhance host immune surveillance and anticancer efficacy.

* Studies may include HDAC-related mechanisms, immunoproteasome regulation, antigen-presentation pathways, and immune-response biomarkers.

Molecular, cellular, and biochemical work

* Design and execute experiments involving epigenetic analyses, immunological assays, and molecular biology, protein biochemistry, and cancer prevention models.

* Experimental procedures may include tissue culture, primary cell culture, 3D spheroid/organoid culture, co-IP, ChIP, PCR, qPCR, flow cytometry/FACS, Western blotting, ELISA, HDAC activity assays, fluorescence microscopy, and related in vitro assays using wild-type and genetically…