Project Chemist (Mass Spectrometry

Project Chemist

Eagle Houston | Eagle
11111 S Wilcrest Dr
Houston, TX 77099, USA

We are seeking a motivated Project Chemist to support routine LC‑MS–based analysis in a fast‑paced laboratory environment. This role is responsible for the timely and reliable execution of LC‑MS/MS workflows, including sample preparation, instrument operation, troubleshooting, and data review. The ideal candidate is comfortable working with minimal supervision, maintaining instrument performance, and delivering high‑quality analytical results in a timely manner.

• Perform routine LC‑MS based assays including peptide mapping, intact mass analysis and protein/small molecule quantitation in a timely and compliant manner
• Prepare samples, standards, mobile phases, buffers, and other laboratory solutions
• Operate and maintain LC‑MS/MS and HPLC/UHPLC systems following SOPs
• Conduct routine analytical runs and monitor instrument performance
• Review, organize, interpret, and document analytical data and laboratory records
• Identify and report unexpected test results, providing initial troubleshooting where applicable
• Perform system suitability, calibration, and QC checks
• Troubleshoot basic instrument and method issues
• Maintain laboratory cleanliness, inventory, and organization
• Support method optimization and validation activities as appropriate
• Collaborate with cross‑functional team members to support project timelines and deliverables

• Bachelor’s or Master’s degree in chemistry, Analytical Chemistry, Biochemistry, or related field
• Hands‑on experience with LC‑MS/MS instrumentation and workflows
• Experience with mass spectrometry–based protein and peptide characterization, including sample preparation, instrument operation, and data analysis, preferred
• Experience with LC‑MS/MS quantitation using MRM and/or SIR acquisition modes preferred
• Hands‑on experience with HPLC or UHPLC systems
• Familiarity with biological and/or chemical sample matrices
• Experience with basic wet chemistry and sample preparation techniques
• Familiarity with GMP (Good Manufacturing Practices) and applicable regulatory requirements (e.g., FDA, ICH)
• Strong attention to detail, organizational skills, and documentation practices
• Comfortable working with laboratory software and data management systems
• Ability to work independently as well as collaboratively in a team environment
• Strong verbal and written communication skills

• Hands‑on experience with HPLC, UPLC, and MS instrumentation
• Knowledge of peptide synthesis and purification techniques
• Experience in a pharmaceutical or biotechnology setting
• Understanding of protein chemistry and post‑translational modifications

Equal Opportunity Employer
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