Postdoctoral Associate - LC-MS- Omics

Postdoctoral Associate

The Center for Drug Discovery is a strategic research center at Baylor College of Medicine in Houston, Texas. The lab is looking for a highly self-motivated Postdoctoral Research Associate with extensive experience in liquid chromatography–mass spectrometry (LC–MS) metabolomics, lipidomics, and drug metabolism.

Job Duties:

• Develops, optimizes, and validates LC–MS and LC–MS/MS methods for metabolomics, lipidomics, drug metabolism, and biomarker analysis.
• Performs sample preparation and extraction of metabolites, lipids, drugs, and drug metabolites from cells, tissues, plasma, and other biological matrices.
• Conducts untargeted and targeted metabolomics and lipidomics studies.
• Processes, analyzes, interprets, and visualizes complex mass spectrometry datasets using appropriate computational and statistical tools.
• Performs in vitro drug-metabolism studies that includes incubations with liver microsomes, primary human hepatocytes, and other relevant biological systems.
• Identifies and characterizes drug metabolites using high-resolution mass spectrometry and tandem mass spectrometry.
• Assesses cellular toxicity using biochemical, molecular, imaging, and metabolomics-based endpoints.
• Maintains accurate experimental records and contributes to data interpretation, scientific presentations and manuscripts.
• Performs other job-related duties as assigned.

Minimum Qualifications:

• MD or Ph.D. in Basic Science, Health Science, or a related field. No experience required.

Preferred Qualifications:

• PhD or equivalent doctoral degree in analytical chemistry, pharmacology, pharmaceutical sciences, biochemistry, metabolomics, or a related discipline.
• Demonstrated expertise in metabolomics and/or lipidomics, including sample preparation, instrument operation, data processing, and biological interpretation.
• Experience with high-resolution LC–MS platforms, especially Thermo Orbitrap Exploris MS.
• Proficiency with metabolomics and lipidomics data-analysis software and multivariate statistical methods.
• Experience with primary human hepatocytes or other physiologically relevant cell models.
• Experience with imaging mass spectrometry, including MALDI or DESI imaging, would be a significant advantage.
• Experience with mammalian cell culture and drug-induced toxicity studies.
• Strong publication record in mass spectrometry, metabolomics, lipidomics, drug metabolism, toxicology, or related fields.
• Strong organizational, analytical, troubleshooting, and scientific communication skills.

Requisition