Post Doctoral Fellow - Pharmacological & Pharmaceutic Department
Listed on 2026-09-03
-
Research/Development
Research Scientist
Department:
Pharmacological & Pharmaceutical Sciences
Salary: $49,400 - $56,200
Possesses, understands, and applies a comprehensive knowledge in area of specialization. Develops understanding and skills to allow for completion of assignments that cross fields of specialization. Develops leadership and management skills.
The Egly Laboratory at the University of Houston College of Pharmacy is seeking to recruit a highly motivated postdoctoral fellow to join a growing research program.
Current Research AreasOur laboratory focuses on ion channel function and molecular pharmacology, investigating how drugs, disease-associated mutations, and polygenic risk variants alter channel gating, trafficking, and permeation. We combine patch-clamp electrophysiology, high-throughput drug and genetic screening, affinity purification-mass spectrometry proteomics, and CRISPR gene editing to dissect these mechanisms. A particular strength of the lab is the use of human iPSC-derived models to assess polygenic risk — testing how combinations of common variants collectively shape channel function and disease susceptibility.
A central goal of the lab is to translate these mechanistic insights into new therapeutic strategies for ion channel disorders.
- Ion Channel Biology
- Molecular Pharmacology
- Cellular Electrophysiology
- iPSC Disease Modeling / Genetic Risk
- Drug Discovery
- Gene Therapy / CRISPR-based Approaches
- Related biomedical research fields
Applicants should possess:
- A Ph.D., M.D., or equivalent degree in pharmacology, cell biology, biophysics, or a related field
- Strong foundational skills in molecular and cellular biology
- Excellent communication and teamwork skills
- A strong work ethic and enthusiasm for scientific research
Experience with molecular cloning, plasmid design, and site-directed mutagenesis
CRISPR / Gene EditingExperience with CRISPR-Cas9 gene editing, including guide RNA design and generation of knock-in/knockout cell lines
Cell Culture (HEK / hiPSC)Experience with mammalian cell culture, including HEK
293 cells and/or maintenance and differentiation of human iPSCs
Experience with patch-clamp electrophysiology (manual or automated platforms) or other electrophysiological techniques
High-Throughput ScreeningExperience with high-throughput screening platforms (e.g., thallium flux assays, automated patch-clamp systems, fluorescence-based assays)
Proteomics / Mass SpectrometryExperience with affinity purification-mass spectrometry (AP-MS) or other proteomic approaches
Bioinformatics / Data AnalysisExperience with bioinformatics tools and computational analysis of genomic, proteomic, or electrophysiological data
BiochemistryExperience with standard biochemical techniques (e.g., Western blotting, co-immunoprecipitation, protein purification)
Successful candidates should be highly self-motivated, intellectually curious, and committed to pursuing innovative and impactful research.
MQ:
Requires singular knowledge of a specialized advanced professional discipline or the highest level of general business knowledge, normally acquired through attainment of a directly job-related terminal degree or equivalent formal training in a recognized field of specialization that is directly related to the type of work being performed. No experience is required.
All positions at the University of Houston-System are security sensitive and will require a criminal history check.
The University of Houston System and its universities are Equal Opportunity Institutions. Everyone is encouraged to apply.
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