Senior Manager, Clinical Trial Supplies

Company Overview

Crinetics is a pharmaceutical company based in San Diego, California, focused on developing therapies for endocrine diseases and endocrine‑related tumors. With a strong discovery engine, robust pipeline and a patient‑centric culture, the company provides an inclusive, team‑oriented, dog‑friendly environment for scientists and clinicians.

The Senior Manager, Clinical Trial Supplies is responsible for the planning, execution, and oversight of global clinical trial supply operations across multiple clinical programs. This role ensures the timely, compliant, and cost‑effective delivery of investigational products, ancillary supplies, and related materials to support clinical studies across all phases.

• Develop and lead end‑to‑end clinical supply strategies for multiple clinical programs and phases (Phase I–IV).
• Design optimized supply models, including labeling, packaging, distribution, and inventory strategies.
• Assess and mitigate supply risks, including demand uncertainty, enrollment variability, and manufacturing constraints.
• Manage clinical trial supply lifecycle activities, including forecasting, demand planning, packaging, labeling, distribution, returns, and destruction.
• Ensure uninterrupted supply of investigational and comparator products to global clinical sites.
• Manage Interactive Response Technology (IRT) system builds, UAT testing, supply strategies and reconciliation activities.
• Partner closely with Clinical Operations, Manufacturing, Quality, Regulatory Affairs, Finance, and external vendors to align on study timelines and deliverables.
• Serve as the clinical supply representative on study teams and governance forums.
• Influence study design decisions to optimize supply chain efficiency and patient experience.
• Lead selection, contracting, and performance management of external vendors (CMOs, depots, couriers, IRT providers).
• Develop and manage clinical supply budgets, vendor quotes, proposals, and timelines.
• Drive cost optimization while maintaining quality and compliance.
• Confirm production plans and shipping schedules; develop depot/site resupply strategies and coordinate packaging schedules with third‑party providers to support clinical demand changes.
• Work with third‑party providers to develop detailed project plans and timelines for packaging, release, and distribution of clinical supplies.
• Coordinate the review and approval of provider documentation (distribution instructions, label proofs, packaging specifications, packaging batch records, etc.).
• Plan and oversee the implementation of expiry date extensions.
• Coordinate assessment and track temperature excursions during storage, receipt, or transit.
• Support the transportation and disposition of returned/unused materials as needed.
• Manage activities needed to source comparators and ancillary products, plan supply strategies, labeling and distribution.
• Support the development of SOPs and guidelines related to third‑party provider management, inventory management, distribution, transportation, and disposition of returned/unused materials.
• Support the CMC team as needed.
• Other duties as assigned.

• Minimum of a Bachelor’s degree in life sciences, nursing, business or related field with at least 8 years of related technical experience, or a Master’s degree with 6 years of experience.
• Previous experience in Project Management, Pharmaceutical Development, Clinical Supply Management, and/or Clinical Trials Coordination.
• Experience in rare diseases and oral solid dosage forms is a plus.
• Experience with import and export management of drug substance and drug product.
• Understanding of CGMP and CGCP requirements, compendia testing, ICH and regulatory guidelines including stability data requirements.
• Excellent interpersonal and communication skills (written and oral).
• Experience with preparation of regulatory documents is desired.
• Excellent ability to work in a goal‑and‑team‑oriented setting and handle competing priorities.
• Flexibility within a rapidly changing environment and high attention to detail.
• Well‑developed organizational skills and ability to thrive under pressure.
• Well‑versed in industry…