Senior Director Center of Excellence Lead

Company Overview

Crinetics is a pharmaceutical company based in San Diego, California that develops therapies for rare endocrine diseases. The company is driven by science, a patient‑centric culture, and a collaborative team environment.

The Senior Director, Real‑World Evidence leads the Real‑World Evidence Center of Excellence (RWE COE) within HEOR/RWE. This role designs, executes, and delivers real‑world studies across the Crinetics portfolio, building enterprise data infrastructure, setting methodological standards, and driving evidence generation.

• Lead delivery of the real‑world evidence program across the portfolio, translating evidence priorities into rigorous, well‑designed real‑world studies.
• Provide leadership, career management, coaching, and mentoring to a team of RWE Scientists; recruit, develop talent and align team capacity to portfolio demand.
• Drive team objectives, prioritization, and resource allocation across competing therapeutic area needs and across long‑range lifecycle planning and near‑term execution horizons.
• Design and oversee burden‑of‑illness, natural history, patient journey, drug utilization, external control arm, comparative effectiveness, and HTA‑supportive real‑world studies.
• Contribute to the design and operationalization of Crinetics‑sponsored registries and lead registry‑related analytics and evidence generation.
• Lead analyses using large healthcare databases and primary real‑world data collection methods.
• Establish methodological standards, protocol templates, statistical analysis frameworks, and quality benchmarks.
• Conduct and supervise feasibility assessments, database selection, and study‑design innovation.
• Partner with IT and Commercial to shape enterprise real‑world data sourcing and analytics infrastructure.
• Lead the RWE module of CrinRADAR, supporting scalable and automated evidence generation.
• Establish data governance, contracting, and vendor management standards for real‑world data assets.
• Partner with HEOR Therapeutic Area Leads to translate franchise‑level evidence questions into executable plans.
• Contribute evidence to integrated evidence plans, value dossiers, and HTA submissions.
• Collaborate cross‑functionally with Clinical Development, Biometrics, Regulatory, and Patient Advocacy.
• Build and steward external partnerships with academic investigators, data providers, and analytics vendors.
• Lead publication strategy and external scientific communication for the real‑world evidence program.
• Represent Crinetics at scientific congresses and remain current with evolving real‑world evidence methodologies and guidance.
• Ensure compliance with corporate policies and applicable healthcare laws and regulations.
• Other duties as assigned.

• Advanced degree in epidemiology, biostatistics, health services research, health economics, or related discipline (PhD, MD, PharmD, MPH, MSc).
• Minimum 13 years of relevant pharmaceutical, biotechnology, or HEOR consulting experience.
• Minimum 10 years of supervisory experience.
• Demonstrated expertise in designing and executing observational studies using large real‑world datasets across the product lifecycle.
• Experience leading center‑of‑excellence or function‑level real‑world evidence programs across multiple assets.
• Experience building and managing external real‑world data vendor partnerships.
• Working knowledge of regulatory and HTA evidence requirements.
• Experience delivering real‑world evidence into value dossiers and HTA submissions.
• Strong analytical, quantitative, and methodological expertise.
• Excellent communication and interpersonal skills with the ability to influence senior leaders.
• Ability to lead, collaborate, and influence cross‑functional teams.
• Flexible, adaptable, and effective in ambiguous environments.
• Preferred:
  Experience in commercial‑stage biotechnology or pharmaceutical organizations.
• Preferred:
  Experience integrating advanced analytics or AI‑enabled platforms into real‑world evidence workflows.
• Preferred:
  Familiarity with ex‑U.S. real‑world evidence requirements.

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