Senior Director, DMPK

Crinetics Overview

Crinetics is a pharmaceutical company based in San Diego, California, developing therapies for endocrine diseases and endocrine‑related tumors.

The Senior Director, DMPK, reporting to the Vice President, DMPK, will apply their strong scientific training in DMPK and hands‑on experience addressing ADME liabilities across drug discovery and development programs. The ideal candidate will have a demonstrated history of leading high‑performing DMPK teams within the biotechnology or pharmaceutical industry and contributing to the development of strategic plans, objectives, and practices for the broader DMPK function.

In this role, the individual will work closely with chemists, biologists, and toxicologists to develop strategies that advance discovery programs into the clinic and collaborate with Clinical Pharmacology and CMC teams to address drug metabolism and clinical drug‑drug interaction issues during both early and late‑stage development.

• Provide strategic leadership and oversight for the Drug Metabolism and Pharmacokinetics function within Discovery.
• Lead the development and execution of DMPK strategies for candidate evaluation, including the continued expansion and optimization of training, methodologies, and equipment.
• Serve as the DMPK representative on multifunctional discovery and early development program teams.
• Partner with Discovery colleagues to define optimal lead candidate characteristics, establish appropriate testing strategies, and design, conduct, and report preclinical studies that efficiently characterize potential drug candidates.
• Foster effective cross‑functional collaboration, particularly with invitro and invivo Pharmacology and Toxicology, and provide guidance on lead optimization, PK/PD understanding, and human dose projections.
• Oversee and contribute to the preparation of preclinical pharmacokinetic sections of regulatory documents, including INDs, NDAs, briefing books, and Investigator Brochures.
• Foster a team culture that promotes continuous improvement, accountability, professional growth, and inclusion.
• Recommend, initiate, and lead innovative technologies and approaches that enhance scientific impact and operational efficiency while ensuring the application of cutting‑edge science to project‑related challenges.
• Build strong partnerships across Crinetics, serve as a subject matter expert, and educate cross‑functional teams on the application of DMPK principles to drug development.
• Identify the need for clinical drug interaction studies based on a strong understanding of metabolic and transporter‑mediated drug interactions.
• Serve as a subject matter expert and support responses to regulatory queries related to DMPK.
• Partner with Discovery leadership to recruit scientists and build teams that support the DMPK strategy and advance the discovery and development portfolio.
• Perform other duties as assigned.

Required:

PhD in a relevant discipline with 13+ years of relevant experience in the pharmaceutical or life sciences industry.

Applicants with a BS or MS of the discipline may apply, but must demonstrate a minimum of 15+ years of significant and relevant experience. Minimum supervisory experience of 10+ years. Excellent verbal, written, and interpersonal communication skills are required. Prior experience working at a small to mid‑sized company with wide‑ranging related responsibilities is desired. Excellent problem‑solving ability, demonstration of cross‑functional understanding related to drug discovery and development, good judgment of risks, leadership and management skills, and excellent negotiation skills are essential.

On a continuous basis, sit at a desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25lbs. may be required. The noise level in the work environment is typically low to moderate. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.

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