Scientist , Radiochemistry

Position: Scientist I, Radiochemistry
Location: Indianapolis

At Rayze Bio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, Rayze Bio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer.

Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients. Learn more about Rayze Bio:  Scientist I, Radiochemistry – Isotope Production will be responsible for taking a lead technical role in both R&D radio chemical and analytical methods supporting various isotope programs  Scientist’s role will be to support the development, optimization, and scale-up of radio chemical processes to produce Actinium-225 through cyclotron irradiation of Radium-226 targets.

This role will focus on radio chemical separations, process engineering, automation, and manufacturing readiness associated with alpha-emitting isotopes. This individual will play a key role in translating laboratory-scale concepts into robust, scalable production processes suitable for implementation in shielded hot cells and GMP manufacturing facilities. Additional responsibilities may be assigned as required to bring technical expertise to Rayze Bio initiatives.

Job Responsibilities Essential duties and responsibilities include the following. Other duties may be assigned.

Design, execute, and optimize radio chemical processes associated with the production, purification, and recovery of Actinium-225 and related isotopes.

Develop and implement separation and purification methods using chromatography, precipitation, solvent extraction, and other radio chemical techniques.

Support process scale-up from benchtop experiments to shielded hot cell operations.

Perform hands-on work with radioactive materials, including alpha-emitting isotopes, while maintaining strict adherence to radiological safety practices.

Develop process flow diagrams, equipment specifications, operating procedures, and technical reports.

Collaborate with engineering teams on process equipment design, automation systems, shielding requirements, and facility integration.

Participate in target processing development, radionuclide recovery strategies, waste minimization efforts, and process troubleshooting.

Evaluate emerging technologies and scientific literature to improve isotope production efficiency, reliability, and throughput.

Generate and analyze experimental data using statistical and scientific methods to guide process decisions.

Support technology transfer activities into manufacturing environments.

Uses AI tools to enhance individual productivity and quality of work Contribute to regulatory documentation, safety reviews, and manufacturing readiness assessments as needed.

Mentor junior scientists and technicians while promoting a culture of scientific rigor and operational excellence.

Less than 5% of travel is required

Education and Experience BS/MS with 5+ years of experience, and/or 3+ years of hands-on experience in Radiochemistry or other scientific equivalent working with open-source radioactive materials.

PhD with 1+ years of experience in Radiochemistry or other scientific equivalent work experience.

Skills and Qualifications Direct experience with Actinium-225, Radium-226, Thorium-229, Thorium-228, Radium-224, or other alpha-emitting isotope systems.

Experience with hot cells, glove boxes, shielded enclosures, and remote handling systems.

Familiarity with cyclotron-produced radioisotopes and post-irradiation target processing.

Experience with ion exchange chromatography, extraction chromatography, solvent extraction, and radionuclide recovery methods.

Experience with process automation, fluid handling systems, or automated separation equipment.

Proficiency with analytical instrumentation such as HPGe spectroscopy, alpha spectroscopy, ICP-OES, ICP-MS, liquid scintillation counting, or…