Director, Site and CMC Program Management

At Rayze Bio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, Rayze Bio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do.

From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients. Learn more about Rayze Bio:

The Director, Program Management will provide strategic leadership and operational oversight for Indianapolis site-based and end-to-end CMC programs. This role will serve on the site leadership team, partner with Product Development and Operations leadership, build core program management capabilities, and ensure effective portfolio delivery across process development, supply chain, production, and related functions.

• Serve on the Indianapolis site leadership team to drive strategic priorities and ensure alignment with Product Development and Operations leadership.
• Build and lead the Program Management team, including planning capabilities, systems, processes, governance routines, and KPIs to drive execution.
• Ensure CMC portfolio delivery by partnering across global product teams, key functions--process development, supply chain, production, quality, regulatory, engineering, and external partners.
• Translate strategic priorities into integrated plans, timelines, decision points, risk mitigation strategies, and performance reporting.
• Lead prioritization and escalation discussions to align resources, resolve barriers, and maintain focus on business and patient-impact priorities.

• Manage integrated CMC program planning and execution across site operations, global program teams, Product Development functions, Quality, Regulatory, Finance, and Commercial stakeholders.
• Coordinate key site and portfolio initiatives, including manufacturing readiness, technology transfer, supply chain planning, engineering projects, CAPA related initiatives, and operational readiness.
• Identify critical path risks, dependencies, resource constraints, and execution barriers; drive mitigation planning and timely escalation.
• Facilitate effective governance forums with clear agendas, decisions, actions, owners, and follow-through.

• Recruit, develop, and manage program management talent to support evolving CMC and site priorities.
• Define PM accountabilities, decision rights, escalation pathways, standards, tools, templates, and ways of working.
• Strengthen program management maturity through critical path analysis, scenario planning, executive communication, governance preparation, and performance tracking.
• Foster a culture of accountability, collaboration, risk management, continuous improvement, and clear communication.

• Prepare concise updates, dashboards, decision materials, and executive communications for site leadership and governance forums.
• Translate complex technical, operational, and portfolio information into clear insights, recommendations, and actions.
• Serve as a bridge across site operations, global program teams, external partners, and enterprise leadership.
• Promote transparency by surfacing risks, issues, decisions, and trade-offs early through appropriate governance channels.

• Bachelor’s degree in life sciences,…