Director - Oligonucleotide Analytical Chemistry

Role Summary

Director - Oligonucleotide Analytical Chemistry leads analytical characterization and development for oligonucleotides, antibody-oligonucleotide conjugates and peptide-oligonucleotide conjugates. Responsible for technical integrity, compliance, and business administration of the Lilly Genetic Medicine analytical team across sites, setting the overall strategy and ensuring capacity, capabilities, and processes are developed and sustained to deliver information to project teams.

Location:

On-site, Indianapolis, IN.

• Provide technical leadership for Lilly Genetic Medicine (LGM) analytical activities to be driven within the organization including analytical characterization, biophysical characterization, downstream processing method development, open-access QC workflows, analytical IT and analytical instrumentation and operation readiness. Ensure methods are technically sound, well developed, and fit-for-purpose.
• Partner with the Early Phase Development team and the drug discovery team to define and deliver appropriate analytical data packages to support molecules advancing from discovery to development
• Mentor and develop scientific team. Ensure continued technical and professional growth of group members, encourage efforts towards excellence and knowledge sharing.
• Plan and manage short-term and long-term analytical investments to support the organization. Develop and/or review technical agendas and timelines for project work. Recommend resource allocation to accomplish projects according to plans, communicate with LGM leadership on progress and propose changes in timeline, objectives, or direction.
• Demonstrate high learning agility and the ability to understand and exploit effective scientific concepts and methods across multiple novel drug modalities, including oligonucleotides, antibody-oligonucleotide conjugates and peptide-oligonucleotide conjugates
• Manage collaborative partnerships with external and internal analytical vendors to supplement LGM analytical resources

• Required:
  
  Ph.D. in analytical chemistry, bioanalytical chemistry, or a related field with 7+ years of experience in the biopharmaceutical sector following graduation
• Required:
  
  2+ years of experience in people management and analytical laboratory operations
• Preferred:
  Demonstrated expertise leading analytical efforts in pharmaceutical product discovery and/or development with proven skills developing and validating analytical methods
• Preferred:
  Experience with technical transfer of analytical methods from discovery to development organizations
• Preferred:
  Demonstrated expertise in leading separation sciences for oligonucleotides, including but not limited to RP, HILIC, HIC, IEX, SEC, and CE
• Preferred:
  Demonstrated experience in scale-up sample preparation and analytical characterization of oligonucleotides, antibody-oligonucleotide conjugates and/or peptide-oligonucleotide conjugates
• Preferred:
  Solid understanding of chemical synthesis, purification and formulation requirements of drug candidate molecules
• Preferred:
  Proficiency in biophysical and analytical characterization techniques, including but not limited to light scattering methods, chromatography, mass spectrometry, back grounded membrane imaging, and other molecular-level characterization tools

• Ph.D. in analytical chemistry, bioanalytical chemistry, or a related field

• Travel: 15 to 20%
• Location:
  
  On-site, Indianapolis, IN