Principal Scientist, Bioanalytical Research

Organization Overview

The Bioanalytical Research Group (BAR) at Lilly’s research facility in Indianapolis, IN seeks a strong scientist skilled in protein and oligonucleotide mass spectrometry to innovate the evaluation of the ADME properties of therapeutic proteins and genetic medicine modalities. The team collaborates with Investigative ADME, Toxicology, Oncology, and Biotechnology Discovery Research to discover and characterize optimal therapeutic candidates to advance to clinical testing.

Develop and apply QQQ and high-resolution LC/MS approaches to characterize the PK, biotransformation, and biodistribution of therapeutic proteins and new drug modalities in pre-clinical animal models; serve as the bioanalytical representative with project teams to achieve project milestones; prioritize workload and mentor staff scientists within a broad field bioanalytical team.

• M.S. in biochemistry, molecular biology, bioengineering, biology, pharmacology, chemistry, or an equivalent field and 4+ years of work experience (or a B.S. with 6+ years).
• Experience developing and implementing Orbitrap mass spectrometry applications to investigate the ADME properties of therapeutic proteins and new modalities (Large Molecules).
• Experience with wet biochemistry and sample preparation techniques involved in isolating biotherapeutics from biological matrices.
• Qualified applicants must be authorized to work in the United States on a full‑time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F‑1 CPT, F‑1 OPT, F‑1 STEM OPT, J‑1, H‑1B, TN, O‑1, E‑3, H‑1B1, or L‑1.

• Expertise in bioanalysis of siRNA or Antibody‑Oligonucleotide Conjugates (AOC) is highly preferred, with experience assessing PK, efficacy, and toxicology profiles in preclinical models and presenting data to project teams.
• Knowledge of the ADME principles of biotherapeutic drugs; experience with proteomics methods, DDA, nano‑LC, DIA, or similar workflows in a drug discovery setting; additional experience with automation, higher throughput methodologies, and biotransformation software tools.
• Excellent written and verbal communication skills; strong work planning, record‑keeping, and data analysis skills.

For individuals who require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form  for further assistance. Note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is a proud EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $65,250 – $193,600. Full‑time equivalent employees will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company‑sponsored 401(k), pension, vacation benefits, medical, dental, vision, and prescription drug benefits;

flexible benefits such as healthcare and/or dependent day‑care flexible spending accounts; life insurance and death benefits; certain time‑off and leave of absence benefits; and well‑being benefits including an employee assistance program, fitness benefits, and employee clubs and activities. Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs at its sole discretion.