Principal Scientist, Molecules Mass Spectrometry

Organization Overview

At Lilly, we unite caring with discovery to make life better for people around the world. The Bioanalytical Research Group (BAR) at Lilly’s research facility in Indianapolis, IN is seeking a strong scientist skilled in protein and oligonucleotide mass spectrometry to deliver innovative ways in our evaluation of the ADME properties of therapeutic proteins and genetic medicine modalities. The team collaborates with Investigative ADME, Toxicology, Oncology, and Biotechnology Discovery Research to discover and characterize optimal therapeutic candidates to advance to clinical testing.

• Develop and apply QQQ and high‑resolution LC/MS approaches to characterize PK, biotransformation, and biodistribution of therapeutic proteins and new drug modalities in pre‑clinical animal models.
• Serve as the bioanalytical representative with project teams to achieve project milestones.
• Prioritize workload and mentor staff scientists within a broad bioanalytical team.

• M.S. in biochemistry/molecular biology, bioengineering, biology, pharmacology, chemistry, or equivalent field and 4+ years of work experience (or a B.S. with 6+ years).
• Experience developing and implementing orbitrap mass spectrometry applications to investigate the ADME properties of therapeutic proteins and new modalities (Large Molecules).
• Experience with wet biochemistry and sample preparation techniques involved in isolating biotherapeutics from biological matrices.
• Authorized to work in the United States on a full‑time basis;
  Lilly does not provide support for or sponsor work authorization or visas for this role.

• Expertise in bioanalysis of siRNA or Antibody‑Oligonucleotide Conjugates (AOC) is highly preferred.
• Experience assessing PK, efficacy, and toxicology profiles in preclinical models and presenting data to project teams.
• Knowledge of the ADME principles of biotherapeutic drugs.
• Experience with proteomics methods, DDA, nano‑LC, DIA, or similar workflows in a drug discovery setting.
• Additional experience with automation, higher throughput methodologies, and biotransformation software tools.
• Excellent written and verbal communication skills. Strong work planning, record keeping, and data analysis skills.

The anticipated wage for this position is $65,250 – $193,600. Full‑time employees also will be eligible for a company bonus (depending, in part, on company and individual performance). Lilly offers a comprehensive benefit program including a company‑sponsored 401(k), pension, vacation benefits, medical, dental, vision, and prescription drug benefits, flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts), life insurance and death benefits, certain time off and leave of absence benefits, and well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.