Advisor​/Senior Advisor Biophysical Characterization

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work worldwide to discover, develop, and deliver life‑changing medicines. Verve Therapeutics, a wholly owned subsidiary of Lilly, focuses on protecting the world from heart disease by developing transformative, once‑and‑done therapies for coronary heart disease.

• Develop, optimize, and execute analytical methods for release and stability testing, product characterization, high‑throughput analysis, and characterization of complex raw materials.
• Review, interpret, and present data within the analytical team and cross‑functionally.
• Provide technical oversight for troubleshooting and phase‑appropriate qualification and validation of analytical assays for gRNA, mRNA, and LNP, coordinating method transfer within the organization or at CMOs/CTLs.
• Author, review, and revise technical source documents to support phase‑appropriate comparability.
• Serve as the CMC representative on cross‑functional project teams.
• Provide technical oversight to guide analytical/QC investigations, as needed.
• Collaborate with internal and external process development and quality teams.
• Train and mentor junior team members.

• Hands‑on experience developing and troubleshooting analytical methods for complex and heterogeneous systems (e.g., HPLC/UPLC, capillary electrophoresis, cryo‑TEM, NMR, MALS, DLS, NTA).
• Previous experience developing methods for gRNA, mRNA, and LNPs.
• Excellent scientific knowledge in analytical chemistry with an understanding of solid‑phase oligonucleotide synthesis and purification strategies.
• Hands‑on experience analyzing DNA/RNA using various techniques (e.g., IP‑RP, IEX, LC‑fluor, multi‑modal LC).
• Advanced understanding of lipid nanoparticle delivery, production, and purification.
• Familiarity with applicable ICH regulations and multi‑compendial guidelines related to method validation.
• Experience in assay development, qualification, validation, and implementation to support transition from non‑GxP to GMP environments.

• Proactive, creative, and positive attitude.
• Effective oral and written communication skills.
• Demonstrated scientific and people leadership skills.

• Travel to the Verve Boston site required.
• Potential exposure to chemicals, allergens, and loud noises.
• Position location:
  
  Indianapolis, IN;
  Lilly Technology Center‑North (LTC‑N).

Full‑time equivalent: $126,000 - $204,600 per year, with potential company bonus based on performance.

Lilly offers a comprehensive benefit program including 401(k) retirement plans, pension, vacation and paid leave, medical, dental, vision, prescription drug coverage, flexible spending accounts, life insurance, disability and death benefits, employee assistance programs, and wellness activities.

Lilly is an equal‑employment‑opportunity employer and does not discriminate based on age, race, color, religion, gender identity, sex, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Lilly is committed to helping individuals with disabilities actively engage in the workforce. To request an accommodation, please complete the accommodation request form at  This form is for accommodation requests only and will not receive a follow‑up response.