Principal Research Scientist - Medicinal Chemist

Location: Indianapolis

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Principal Research Scientist - Medicinal Chemist####

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** At Elanco (NYSE: ELAN) - it all starts with animals!
**** As a global leader in animal health, we are dedicated to innovation and delivering products and services to prevent and treat disease in farm animals and pets.*
* ** At Elanco, we are driven by our vision of Food and Companionship Enriching Life and our purpose - all to Go Beyond for Animals, Customers, Society and Our People.
**** At Elanco, we pride ourselves on fostering a diverse and inclusive work environment. We believe that diversity is the driving force behind innovation, creativity, and overall business success. Here, you'll be part of a company that values and champions new ways of thinking, work with dynamic individuals, and acquire new skills and experiences that will propel your career to new heights.
**** Making animals' lives better makes life better - join our team today!
**** Your Role:
**** Principal Research Scientist - Medicinal Chemist
** As a Principal Research Scientist in Medicinal Chemistry, you will be a key figure in our small molecule drug discovery engine, guiding the design and synthesis of innovative medicines that improve the health and well-being of animals. You will apply your scientific expertise to advance multiple therapeutic programs, from lead generation to development candidate selection. Partnering with a global, cross-functional team of scientists, you will leverage cutting-edge technologies like AI/ML and DNA-Encoded Libraries to solve complex chemical challenges.

This is an exciting opportunity to make a significant impact on our discovery portfolio and help shape the future of our growing research team in Indianapolis.
** Your Responsibilities:
*** Guide the design and optimization of novel small molecules by applying advanced synthetic strategies and integrating biological, pharmacological, and ADME/PK data to manage Structure-Activity Relationship (SAR) campaigns.
* Serve as a key medicinal chemistry figure on multidisciplinary project teams, collaborating with partners in Biology, Pharmacology, DMPK, Toxicology, and Computational Sciences to strategically advance discovery programs.
* Manage and coordinate synthetic chemistry efforts with external Contract Research Organizations (CROs) and internal partners, ensuring the efficient execution of project goals and timelines.
* Leverage cutting-edge drug discovery technologies, including DNA-Encoded Libraries (DEL), computational chemistry, and AI/ML-enabled tools, to accelerate hit identification and lead optimization.
* Promote scientific excellence and data integrity while providing mentorship and technical guidance to junior scientists, fostering a culture of innovation and collaboration.
** What You Need to Succeed (minimum qualifications):**
* *
* Education:

** PhD in Medicinal Chemistry, Organic Chemistry, or a related scientific discipline.
* *
* Experience:

** A minimum of 6 years of relevant industry experience in medicinal chemistry within a pharmaceutical, biotechnology, or animal health research environment.
* ** Top

Skills:

** Demonstrated expertise in modern medicinal chemistry, including the design and multi-step synthesis of complex small molecules, and a strong understanding of…