Director​/Senior Director​/Executive Director – Translational PKPD Project Leader

Lilly, headquartered in Indianapolis, Indiana, is an international company dedicated to discovering and developing innovative medicines that improve patients’ lives. We are seeking a Scientific Director with expertise in mechanistic PK/PD and PBPK modeling of novel modalities.

• Serve as the Discovery PK/PD project leader for genetic medicines programs, including ASOs, siRNA, LNP‑mediated delivery, gene therapy (AAV and non‑viral vectors), and antibody‑siRNA conjugates (ARC).
• Develop and implement modeling strategies that enhance decision‑making for genetic medicines and inform translational research strategies.
• Design, analyze, and interpret quantitative pharmacology and PK/PD studies.
• Collaborate effectively with scientists within and outside the functional area to integrate PK/PD into team strategy and contribute to project team discussions, guiding key go/no‑go decisions with quantitative approaches.
• Communicate quantitative findings both internally and externally through scientific publications, conference presentations, and cross‑functional forums.
• Mentor junior scientists and contribute to the growth of PK/PD modeling capabilities within the genetic medicines and neuroscience spaces.

• PhD in Pharmacokinetics/Pharmacodynamics, Pharmacology, Pharmaceutical Sciences, Biomedical Engineering, or a related field with at least 5 years of industry or CRO experience in translational and/or mechanistic PK/PD modeling.
• Proven experience with empirical or mechanistic PK/PD modeling to support drug discovery and/or development.
• Experience with DMPK and translational PK/PD modeling for interspecies scaling, human dose projections, and first‑in‑human study design.
• Experience with computational modeling and simulation software such as NONMEM, mrgsolve, MATLAB, Monolix, SimCYP, PKSim, or equivalent platforms.
• Effective collaboration in a cross‑functional, matrixed environment.

• Prior people‑management experience, including management in a matrix environment.
• Experience with PK/PD or PBPK modeling of oligonucleotide therapeutics (ASO, siRNA), LNP delivery platforms, gene therapy (AAV or non‑viral), and/or antibody‑siRNA conjugates (ARCs).
• Knowledge of disposition, intracellular delivery, tissue distribution, pharmacodynamics, and durability of nucleic‑acid‑based therapeutics.
• Strong organizational and self‑management skills with the ability to manage multiple programs simultaneously.
• Publication record in peer‑reviewed journals in quantitative pharmacology, genetic medicines, or related fields.

Annual salary range: $177,000 – $308,000. Eligible for a company bonus.

• 401(k) with company match
• Pension plan
• Paid vacation and sick leave
• Medical, dental, vision, and prescription drug coverage
• Flexible spending accounts
• Life insurance and death benefits
• Well‑being benefits, including employee assistance and wellness programs

Lilly is an equal‑opportunity/affirmative action employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, disability, national origin, or any other protected status. Lilly encourages qualified applicants with disabilities to request accommodations through the following: