Advisor, Physicochemical Properties and Compound Quality

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life‑changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

The Lilly Small Molecule Discovery (LSMD) group is an organization purpose‑built to create molecules that make life better for people. We focus on using innovative science to unlock novel approaches that can treat people suffering from diseases with poor treatment options. We continually challenge ourselves to deliver molecules that can provide breakthrough efficacy with the highest possible safety margins. We are dedicated to optimizing our mindset, technology, and processes for faster, more nimble execution.

Our success is built on a culture that empowers innovative problem‑solving through open collaboration and individual accountability.

• Physicochemical Property Characterization:
  Design and execute experiments to measure key physicochemical properties (e.g., solubility, pKa, logD/P, stability, Polar Surface Area) of new chemical entities (NCEs) and drug candidates in the early stages of discovery. These are either measured directly or via surrogate chromatographic methodology, such as SFC‑MS or LC‑MS. Holistic assessment of these properties in conjunction with other characterization data will guide decisions on SAR, bioavailability, future formulation, and drug delivery.
• LC‑MS Method Development & Application Assessing Critical Quality Attributes:
  Develop and optimize LC‑MS methods for purity, identity, and stability analysis for a variety of pharmaceutical compounds, impurities, and potential drug candidates. Ensure method sensitivity, reproducibility, robustness, and speed of analytical methods to support the discovery timelines.
• Data Analysis & Reporting:
  Process and interpret complex chromatographic and spectrometric data to generate contextualized and actionable results. Present results and conclusions to cross‑functional project teams and key stakeholders to enable rapid and reliable decision making.
• Documentation & Compliance:
  Maintain accurate and detailed laboratory notebooks and reports in accordance with internal company standards. Ensure proper documentation of experimental protocols, results, and any deviations or issues.
• Innovation & Continuous Learning:
  Stay current with advancements in analytical chemistry, LC‑MS techniques, and drug discovery trends. Continuously identify opportunities to enhance laboratory efficiency, improve analytical techniques, and contribute to the scientific knowledge base. Demonstrate scientific rigor to develop new and novel experiments and techniques to enable and speed up the discovery pipeline.
• Cross‑Functional:
  Effectively partner with chemists, pharmaceutical formulation scientists, ADME/DMPK scientists, computational scientists, and data scientists.

• PhD in Analytical Chemistry, Pharmaceutical Sciences, or a closely related discipline with 5+ or Masters with 10+ years of post‑education hands‑on experience with LC‑MS, SFC‑MS, LC‑MS/MS, and physicochemical techniques in a small molecule pharmaceutical discovery environment.

• In-depth proven track record determining physicochemical properties and driving cross‑functional impact on drug design and…