Scientist , Radiochemistry

Company Overview

At Rayze Bio, a wholly‑owned subsidiary of Bristol Myers Squibb, we develop transformative radiopharmaceutical therapies to offer new hope for patients living with cancer. Our multidisciplinary team values innovation, collaboration, and immediate impact on patients, science, and teams.

The Scientist I, Radiochemistry – Isotope Production will lead technical development of radio chemical and analytical methods for isotope programs, primarily supporting the production of Actinium‑225 through cyclotron irradiation of Radium‑226 targets. The role focuses on separation, process engineering, automation, and manufacturing readiness for alpha‑emitting isotopes.

• Design, execute, and optimize radio chemical processes for the production, purification, and recovery of Actinium‑225 and related isotopes.
• Develop separation and purification methods using chromatography, precipitation, solvent extraction, and other radio chemical techniques.
• Support scale‑up from benchtop experiments to shielded hot‑cell operations.
• Perform hands‑on work with radioactive materials, including alpha‑emitting isotopes, while maintaining strict radiological safety practices.
• Develop process flow diagrams, equipment specifications, operating procedures, and technical reports.
• Collaborate with engineering teams on process equipment design, automation systems, shielding requirements, and facility integration.
• Participate in target processing development, radionuclide recovery strategies, waste minimization efforts, and process troubleshooting.
• Evaluate emerging technologies and scientific literature to improve isotope production efficiency, reliability, and throughput.
• Generate and analyze experimental data using statistical and scientific methods to guide process decisions.
• Support technology transfer activities into manufacturing environments.
• Use AI tools to enhance individual productivity and quality of work.
• Contribute to regulatory documentation, safety reviews, and manufacturing readiness assessments as needed.
• Mentor junior scientists and technicians while promoting a culture of scientific rigor and operational excellence.
• Travel is less than 5% of the role.

• BS/MS with 5+ years of experience, and/or 3+ years of hands‑on experience in radiochemistry or a related scientific area working with open‑source radioactive materials.
• PhD with 1+ year of experience in radiochemistry or a related scientific area.

• Direct experience with Actinium‑225, Radium‑226, Thorium‑229, Thorium‑228, Radium‑224, or other alpha‑emitting isotope systems.
• Experience with hot cells, glove boxes, shielded enclosures, and remote handling systems.
• Familiarity with cyclotron‑produced radioisotopes and post‑irradiation target processing.
• Experience with ion exchange chromatography, extraction chromatography, solvent extraction, and radionuclide recovery methods.
• Experience with process automation, fluid handling systems, or automated separation equipment.
• Proficiency with analytical instrumentation such as HPGe spectroscopy, alpha spectroscopy, ICP‑OES, ICP‑MS, liquid scintillation counting, or related techniques.
• Familiarity operating in a GxP setting.
• Excellent scientific data analysis and technical writing skills.
• Excellent professional ethics, integrity, and the ability to maintain confidential information.

This position requires regular sitting, reaching with hands and arms, and speaking or hearing. Occasionally, the employee may lift or move up to 30 pounds. Vision requirements include both close‑ and distance‑vision. Protective clothing, gloves, and safety glasses are required when working in a laboratory environment with radioactive materials. The noise level in the work environment is usually moderate.

Independence, IN: $96,148 – $116,508 per year. Additional incentive cash and stock opportunities (based on eligibility) may be available. Final compensation is determined by demonstrated experience.

• Health Coverage:
  Medical, pharmacy, dental, and vision care.
• Well‑being Support: BMS Well‑Being Account, BMS Living Life Better, and Employee…