Crystallization Process Development Engineer - Drug Substance SMDD

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work-but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Lilly's Synthetic Molecule Design and Development (SMDD) is involved in key activities for the development of active pharmaceutical ingredients and formulated drug products from pre-clinical phases through commercialization of drug substances and drug products for small molecules, synthetic oligonucleotides, and synthetic peptides. Our scientists develop key technical and business solutions across the portfolio using their deep technical expertise to speed up testing of clinical hypothesis and overall drug development.  

SMDD tackles this diversity of responsibilities by recognizing that an even greater diversity of talents and cultures is vital to deliver the next generation of life changing medicines to patients.

** Shape How Tomorrow's Medicines Take Shape*
* Crystallization is where chemistry becomes medicine - the step that determines whether a promising molecule can be reliably purified, formulated, and manufactured 're looking for an outstanding crystallization engineer to join our Crystallization Science team and take ownership of that critical transformation across an exciting and diverse pipeline of small molecules, oligonucleotides, and synthetic peptides.

You'll work in a brand-new, pioneering development facility in Indianapolis, embedded in a highly collaborative environment alongside synthetic chemists, analytical scientists, formulation experts, and process engineers - with the resources and cross-functional support to solve genuinely hard problems, not just implement someone else's protocol.

** What We're Looking For*
* An engineer with strong technical depth in crystallization science and engineering, a track record (or clear potential) for scientific leadership, solid understanding of cGMP and ICH guidelines (Q6A, Q8, Q11), and - just as important - a genuine passion for collaborative, team-based problem solving in a diverse and inclusive environment.

** What You'll Do*
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** Lead crystallization process design end-to-end**  - from first-principles science (nucleation kinetics, crystal growth, supersaturation control, solubility thermodynamics, heat/mass transfer) through robust, scalable processes that deliver clinical trial materials on time and on spec.

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** Innovate across a full toolkit of crystallization strategies**  - cooling, antisolvent, reactive, and seeded crystallization - paired with modern PAT tools (in-situ imaging, FBRM, ATR-FTIR, Raman) and QbD/DoE methodologies to build deep process understanding and real control, not just documentation.

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** Be the go-to crystallization expert
** on integrated drug substance project teams, driving particle engineering strategy (size distribution, morphology, polymorphic form, impurity rejection) and directly influencing regulatory filings (IND, IMPD, NDA) through your own authored content.

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** Bridge bench to plant to patient**  - partner with formulation, analytical, and manufacturing teams to ensure the APIs you develop translate into drug products that actually work, and lead scale-up and technology transfer to pilot plants and external CMOs.

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** Grow as a scientific leader**  - mentor emerging talent, publish and present in venues like AIChE and ACS, and help shape standards and control strategies across the broader organization.

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** Stay at the leading edge**  - engage with academic partners, pre-competitive consortia, and the latest advances in continuous crystallization and particle engineering as part of a culture that values external scientific contribution.

** Minimum Qualifications*
* + PhD in Chemical Engineering

+ MSc in Chemical Engineering +7 years of experience

+ BSc in Chemical Engineering +10 years of experience

** Additional Skills and Preferences*
* + Hands-on experience designing, developing, and optimizing crystallization processes for pharmaceutical APIs - including polymorph screening, solid-form selection, and particle engineering.

+ Fluency with crystallization modeling and simulation tools (population balance modeling, thermodynamic solubility modeling), plus a data-driven approach to DoE and process analytics.

+ Work across both batch and continuous unit operations, with a solid grasp of the technical considerations behind equipment design, process monitoring, and PAT system integration.

+ A natural communicator - someone who can distill complex technical work into clear documentation…