Director - Oligonucleotide Analytical Chemistry

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism.

We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

In this role, we are seeking an experienced scientific leader that will have responsibility for ensuring the technical integrity, compliance, and business administration of a Lilly team responsible for analytical characterization and development of oligonucleotides, antibody-oligonucleotide conjugates and peptide-oligonucleotide conjugates.  The Analytical team consists of high-level scientists focused on the implementation of new technologies and analytical process improvements. This position involves working cross-functionally within the Indianapolis site and with our site in Boston to develop strategic functional capabilities and ensure appropriate capacity, capabilities and business processes are developed, implemented and sustained to deliver the required information to the project teams.  

The scientist will be an external leader in this technical area and set the overall strategy for the Lilly Genetic Medicine analytical team across research sites and in cooperation with our cross-functional partners.

** Responsibilities:*
* + Provide technical leadership for Lilly Genetic Medicine (LGM) analytical activities to be driven within the organization including analytical characterization, biophysical characterization, downstream processing method development, open-access QC workflows, analytical IT and analytical instrumentation and operation readiness. Ensure methods are technically sound, well developed, and fit-for-purpose.

+ Partner with the Early Phase Development team and the drug discovery team to define and deliver appropriate analytical data packages to support molecules advancing from discovery to development

+ Mentor and develop scientific team.  Ensure continued technical and professional growth of group members, encourage efforts towards excellence and knowledge sharing.

+ Plan and manage short-term and long-term analytical investments to support the organization. Develop and/or review technical agendas and timelines for project work. Recommend resource allocation to accomplish projects according to plans, communicate with LGM leadership on progress and propose changes in timeline, objectives, or direction.

+ Demonstrate high learning agility and the ability to understand and exploit effective scientific concepts and methods across multiple novel drug modalities, including oligonucleotides, antibody-oligonucleotide conjugates and peptide-oligonucleotide conjugates

+ Manage collaborative partnerships with external and internal analytical vendors to supplement LGM analytical resources

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* Basic Qualifications:

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* + Ph.D. in analytical chemistry, bioanalytical chemistry, or a related field with 7+ years of experience in the biopharmaceutical sector following graduation

+ 2+ years of experience in people management and analytical laboratory operations

** Additional*
* ** Skills/Preferences:*
* + Demonstrated expertise leading analytical efforts in pharmaceutical product discovery and/or development with proven skills developing and validating analytical methods

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Experience with technical transfer of analytical methods from discovery to development organizations

+ Demonstrated expertise in leading separation sciences for oligonucleotides, including but not limited to RP, HILIC, HIC, IEX, SEC, and CE

+ Demonstrated experience in scale-up sample preparation and analytical characterization of oligonucleotides, antibody-oligonucleotide conjugates and/or peptide-oligonucleotide conjugates

+ Solid understanding of chemical synthesis, purification and formulation requirements of drug candidate molecules

+ Proficiency in biophysical and analytical characterization…