Advisor​/Senior Advisor, Purification Development

Purification Development Scientist

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work—but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

The Bioproduct Research and Development organization strives to deliver creative medicines to patients through the development and commercialization of insulins, monoclonal antibodies, novel therapeutic proteins, peptides, oligonucleotide therapies and gene therapy systems. This organization is a multidisciplinary group that works collaboratively with our discovery and manufacturing colleagues. Located in Indianapolis, scientists have full access to our scientific excellence and engineering capabilities.

Do you enjoy downstream drug substance processes including purifying and filtering monoclonal antibodies, recombinant proteins, viral vectors, bioconjugates and peptides? Do you have experience with process development and tech transfer? Are you skilled in the analytical techniques used to characterize bioproducts? If so, then a role as a Purification Development Scientist is waiting for you.

This role requires a strong scientific foundation, effective interaction and communication of technical information with, but not limited to, Safety, Environmental and Quality Team members, Purification Development colleagues, CMC Team members, Discovery team members, Analytical Services, Tech Service/Manufacturing Science representatives, Operations, Engineering, Regulatory and Maintenance personnel.

Especially important, in this role, is that you adhere to all safety and environmental guidelines and promote a proactive safety culture and environmental compliance in all areas.

As a scientist in the Purification Development group, you will:

• Identify and develop new purification technologies.
• Design optimized downstream drug substance processes for new biologic candidates.
• Maintain accurate records and interpret data to provide detailed information and analysis on the execution of experiments.
• Employ strategic thinking to overcome technical hurdles and oversee process and technical transfer to GMP manufacturing facilities, as they make their way from discovery to the clinic.
• Write technical reports, tech transfer documents and give presentations to summarize development activities.
• Maintain flexibility to accept new projects and challenges.
• Troubleshoot issues as they occur and identify trends and opportunities to reduce process variability.

• PhD in Chemical Engineering or related degree focused on biological separation sciences OR
• MS in Chemistry, Chemical Engineering, or related degree with at least 5 years relevant experience in leading protein purification/process development OR
• BS in Chemistry, Chemical Engineering, or related degree with at least 8 years relevant experience in leading protein purification/process development

• Ability to exhibit a high level of attention to detail, a quality-minded approach to experimental design and record keeping.
• Effective oral and written communication skills
• Strong laboratory skills
• Experience purifying complex bioconjugates (e.g., ADCs, PEGylated proteins, antibody-oligonucleotide conjugates).
• Purification development experience with AAV, mRNA, or other gene therapy strategies.
• Extensive knowledge of membrane filtration
• Ability to interact and form dynamic relationships with a wide range of groups.
• Experience with process control and documentation systems (Unicorn, Empower, electronic laboratory notebooks).
• General interpersonal and communication skills; mentoring, feedback, training, and cultivating an environment for learning and open/honest communication.
• Basic analytical skills and understanding
• Advanced problem-solving skills
• Experience interfacing with CDMOs or external development partners
• Experience supporting late-phase process development activities, such as risk assessment, process characterization, or regulatory filing

The physical demands of this job are consistent with a lab environment.

This position's work environment is in a Laboratory environment.

Lilly is…