Senior Analytical Scientist – Analytical Characterization – Lilly Medicine Foundry

Senior Analytical Scientist – Analytical Characterization

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work—but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development. The first-ever facility of its kind, combining research and manufacturing in a single location, the Medicine Foundry will allow Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines, while also reducing costs and environmental impact.

In the Project Delivery Phase and Startup Phase of the project (2026 to 2028), roles will be fluid and dynamic as we endeavor to support the project delivery, build a new organization, develop and implement the necessary systems and business processes required to support GMP operations. This will require significant collaboration, creativity, and resilience as the Lilly Medicine Foundry goes from design, start-up, and steady-state operations.

The Analytical Characterization group is part of the larger Analytical Science and Technology (ASAT) group and consists of high-level scientists focused on the implementation of new technologies and analytical process improvements. This position involves working cross-functionally within the site and across the network to identify, develop, and employ new technological solutions to deliver the required information to the project teams. This position will be key to ensuring a strong safety culture and establishing safety, quality, and continuous improvement focused mindset within the organization.

The Senior Analytical Scientist – Analytical Characterization role, a technical-track and lab-based position, seeks a collaborative, inclusive, and energetic scientist at the Lilly Medicine Foundry to oversee analytical characterization efforts (e.g., spectroscopy and chromatography) supporting the production of synthetic and biologic drug substance processes. This role will collaborate with the parent Chemistry Manufacturing and Control (CMC) development organizations to understand the needs of the portfolio and analytical methods required to deliver on the control strategy of the drug substance.

This position will work closely with process engineers, synthetic chemists, process analytical scientists, and production staff, and as such, will require good communication and prioritization skills.

Responsibilities:

• Drive implementation of technical solutions and analytical strategies to enable drug substance production at the Lilly Medicine Foundry leveraging traditional off-line testing in the laboratories or in-line/on-line testing via process analytical technology (PAT) on the production floor.
• Select and implement appropriate analytical techniques (e.g., LC, GC, NMR, MS, XRD, etc.) to support chemical process development - independently generating data that elucidates reaction mechanisms, characterizes kinetic behavior, and identifies process-related impurities.
• Provide technical leadership for analytical and biophysical characterization of a wide variety of molecules. Ensure methods are technically sound, well developed, and fit-for-purpose.
• Transfer analytical methods from Product Research and Development laboratories with an emphasis on communication with other analytical scientists while making improvements on test methods to improve robustness, accuracy, precision and other attributes outlined by ICH guidelines.
• Demonstrate high learning agility and the ability to understand and exploit effective scientific concepts…