Sr Principal R​/D Engineer

We anticipate the application window for this opening will close on - 25 Sep 2026 Careers that change lives start here. Medtronic is a global leader in healthcare technology with a Mission to alleviate pain, restore health, and extend life. Our 95,000 employees work across more than 150 countries to put patients first — developing innovative medical technologies that improve the lives of 72+ million patients each year.

Your unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and impact.

The Neuroscience Portfolio delivers therapies that treat disorders of the brain, spine, nerves, and vascular system. Through a broad range of medical technologies, our teams partner with physicians and healthcare systems worldwide to improve patient outcomes and quality of life. The Neurovascular Operating Unit develops technologies that treat acute ischemic stroke, hemorrhagic stroke, and other neurovascular diseases. Our portfolio includes devices designed to restore blood flow, remove clots, and treat complex vascular conditions, supporting physicians in delivering life‑changing therapies to patients worldwide.

This role supports the development, maintenance, and continuous improvement of stent‑based neurovascular devices within a regulated medical technology environment. The engineering team partners closely with Quality, Manufacturing, Regulatory Affairs, Clinical, Supply Chain, and Marketing functions to ensure product performance, compliance, and lifecycle management are maintained while supporting patient outcomes. This is an onsite position based in Irvine, California. Travel is expected to be less than 10% and may include visits to manufacturing sites, suppliers, or company locations as needed.

As a Sr. Principal R&D Engineer, you will serve as a recognized technical leader responsible for the following and other duties may be assigned. Designs, develops, analyzes, troubleshoots and provides technical skills during research and/or product development. Designs studies to investigate specific life science questions within field of expertise. May be involved in product research and development and/or clinical trials.

Translates research discoveries into usable and marketable products. This role focuses on driving product improvements, resolving complex technical challenges, leading design and validation activities, and ensuring compliance with quality system and regulatory requirements. The position requires extensive cross‑functional collaboration, technical mentorship, and strategic leadership to support product performance, business objectives, and long‑term portfolio success.

• Lead engineering activities and strongly influences the design of new products, processes, standards, or operational plans based on business strategy with a significant impact on functional results related to the development, maintenance, and continuous improvement of stent‑based neurovascular devices.
• Implements strategic goals established by functional leadership.
• Changes or may establish operational plans for job area with long‑range impact on results.
• Drive complex investigations, root cause analyses, and corrective and preventive actions (CAPAs) related to product performance, customer feedback, and field issues.
• Partner with Quality, Manufacturing, Regulatory Affairs, Clinical, Supply Chain, and Marketing teams to identify, evaluate, and implement product enhancements.
• Develop and execute test plans, protocols, verification activities, and validation strategies supporting product development, product updates, design changes, and performance improvements.
• Author, review, and approve technical documentation including…