Principal Engineer, Algorithm - ECG

Job Summary

The Principal Engineer, Algorithm - ECG is a senior technical leader responsible for the architecture, development, and advancement of electrocardiogram (ECG) signal processing algorithms that enable accurate, reliable cardiac monitoring in Masimo's non-invasive platforms.

This role drives innovation in ECG-based measurement, including heart rate, rhythm analysis, and advanced cardiac insights, translating complex physiological signals into clinically actionable outputs. The Principal Engineer partners closely with cross-functional teams across hardware, software, systems, and clinical domains to deliver high-performance, regulatory-compliant solutions from concept through commercialization.

• Lead the design and development of advanced ECG signal processing algorithms, including filtering, feature extraction, waveform delineation, and rhythm classification
• Architect scalable algorithm frameworks for ECG analysis, supporting real-time embedded implementation and cloud-based analytics where applicable
• Develop and optimize algorithms for heart rate detection, arrhythmia identification, and ECG morphology analysis
• Design and conduct validation strategies using clinical datasets to ensure algorithm accuracy, robustness, and generalizability across diverse patient populations
• Address signal quality challenges, including motion artifact, noise reduction, and low-perfusion or ambulatory conditions
• Partner with hardware and systems teams to ensure optimal signal acquisition and end-to-end system performance
• Collaborate with software and firmware teams to implement algorithms on embedded platforms with real-time constraints
• Translate clinical and regulatory requirements into algorithm design inputs, ensuring compliance with applicable standards (e.g., FDA, IEC)
• Establish best practices for algorithm verification, validation, and documentation in regulated environments
• Provide technical leadership and mentorship to engineers, contributing to team capability building
• Drive innovation and contribute to intellectual property, including patents and technical publications

• 12+ years of relevant experience in ECG algorithm development, signal processing, or related domain
• Deep expertise in ECG signal processing, digital signal processing, and statistical modeling
• Proven experience developing ECG algorithms, including waveform detection and cardiac feature extraction
• Strong programming skills in C/C++, MATLAB, Python, or similar
• Experience working with large-scale physiological or clinical datasets
• Demonstrated ability to translate complex signal processing challenges into robust, real-time solutions
• Strong problem-solving, analytical, and cross-functional collaboration skills
• Ability to work onsite Monday - Friday in Irvine, CA

• Experience with arrhythmia detection/classification algorithms or cardiac monitoring systems
• Knowledge of cardiac physiology and electrophysiology principles
• Experience applying machine learning techniques to ECG or time-series physiological data
• Familiarity with wearable or ambulatory ECG systems and associated signal challenges
• Experience supporting regulatory submissions (e.g., FDA 510(k), CE Mark)
• Prior contributions to patents, publications, or clinically validated products

Bachelor's degree in Electrical Engineering, Biomedical Engineering, Computer Engineering, or a related field required;
Master's or Ph.D. preferred

• Ability to read, write, and communicate effectively in English
• Ability to interpret technical documents, schematics, and written instructions
• Ability to clearly document technical findings and communicate with cross-functional team members

The anticipated salary range for this position is $170,000 - $215k plus benefits. Actual placement within this range is dependent on multiple factors, including but not limited to skills, education, and experience. This position also qualifies for up to 15% annual bonus based on company, department, and individual performance. Masimo offers benefits such as Medical, Dental, Vision, Life/AD&D, Disability Insurance, 401(k), Vacation,…