Sr. Manager, Strategic Operations & Innovation

McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve – we care.

What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow’s health today, we want to hear from you.

McKesson’s Provider Solutions business is transforming how independent specialty and oncology practices operate, grow, and adopt innovation. We are seeking a Sr. Manager, Strategic Operations & Innovation to lead execution across a portfolio of strategic initiatives, operational transformation efforts, and innovation programs.

This role serves as the operational leader for complex, cross-functional programs, translating strategy into measurable outcomes. You will drive portfolio governance, delivery planning, stakeholder alignment, risk management, and organizational readiness while partnering across business, technology, data, finance, and operations teams.

• Lead execution of a portfolio of strategic initiatives, ensuring priorities, timelines, resources, and dependencies are aligned to business objectives.
• Develop and maintain integrated program plans, milestones, risks, issues, and key decisions across multiple work streams.
• Drive program governance, operating reviews, executive updates, and decision-making processes.
• Partner with business leaders, product teams, technology teams, and external vendors to coordinate delivery and resolve obstacles.
• Manage cross-functional dependencies and ensure accountability for achieving program milestones.
• Develop executive-level presentations, business reviews, and portfolio reporting for senior leadership.
• Identify, assess, and mitigate program risks while escalating critical issues and recommendations as needed.
• Support innovation and commercialization initiatives, helping new solutions transition into sustainable operating models.
• Lead change management and stakeholder engagement activities to promote adoption and organizational readiness.
• Establish operating rhythms, performance tracking, and governance processes that improve execution and business outcomes.

• Bachelor's degree or equivalent experience.
• Typically requires 7+ years of experience in strategic operations, program management, business transformation, management consulting, operational excellence, innovation, or related fields.
• Experience leading complex cross-functional programs involving multiple stakeholders and work streams.
• Experience creating and managing program roadmaps, project plans, dependency tracking, and executive reporting.
• Demonstrated success driving initiatives from strategy through implementation and operational adoption.
• Experience presenting recommendations, progress updates, and business insights to senior leaders.

• MBA or other advanced degree.
• Experience with in healthcare, specialty care, pharmaceutical distribution, or highly matrixed enterprise organizations.
• Experience supporting innovation, incubation, commercialization, or new business initiatives.
• Knowledge of portfolio management, organizational change management, and operational transformation methodologies.
• Experience managing third-party vendors, statement-of-work (SOW) engagements, and delivery governance.
• Proficiency with project and portfolio management tools, reporting platforms, and AI-enabled productivity solutions.
• Strong facilitation,…