Software Engineer, Backend Developer

At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives. We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting‑edge molecular science and AI, we ask ourselves every day: “What would I do if this patient were my mom?”

That question drives everything we do. But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose. Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins.

Caris Life Sciences serves hundreds of thousands of molecular cases a year and continues to grow at double‑digit rates. Its molecular, imaging, and clinical‑outcomes data support software that helps ensure a cancer patient’s report is right, complete, and on time. The Software Engineer – Clinical Software Products designs, implements, tests, and supports features across Caris’s clinical application portfolio, owning well‑scoped work end to end within the team’s engineering and compliance standards.

Assignments span product delivery, reliability, and incremental modernization of the production systems behind regulated clinical workflows: live cases move through them every day, and a patient is waiting on each one. The engineering environment supports advanced AI coding assistants and agentic workflows across design, implementation, and test generation. Characterization tests and golden‑master replay validation carry the burden of proof: they pin current behavior as executable, repeatable evidence.

Onboarding is harness‑first, so an engineer’s first work is building or extending that evidence around the systems they will change. Delivery runs on CI/CD, automated testing, application‑level observability, and risk‑based release governance aligned with current FDA Computer Software Assurance guidance: compliance moves at the pace of delivery. Representative technologies across the portfolio include Java, Type Script, browser‑based application frameworks, server‑side JavaScript, and selected enterprise Java components.

The specific assignment and technology stack are discussed during the interview process. This individual‑contributor role reports to an Engineering Manager or Senior Engineering Manager within Clinical Software Engineering. The engineer builds and maintains clinical software applications subject to SOX financial controls and FDA regulatory requirements. Design participation and scope of ownership grow with demonstrated experience.

Location:

Irving, Texas (Dallas-Fort Worth), on‑site/hybrid, minimum three days per week on campus; co‑located with Caris’s laboratory and clinical operations.

Design, implement, and maintain features and components across assigned clinical software applications. Write well‑structured, testable, and documented code suited to a regulated production environment. Deliver well‑scoped work independently, from requirement refinement through release, raising risks and trade‑offs early. Contribute options and trade‑offs in design and architecture discussions for assigned areas. Give and receive peer code reviews, uphold code‑quality standards, and surface issues that could affect correctness, performance, or compliance.

Partner with product management to refine requirements, identify technical constraints, and estimate backlog items. Write and maintain automated unit, integration, and end‑to‑end tests as a first‑class engineering responsibility. Write the technical documentation the work requires: design notes, architecture decision records, and operational runbooks that meet SOX and FDA change‑control obligations. Instrument, monitor, and support production systems; participate in incident response and root‑cause analysis with the team.

Automate the recurring engineering…