Post-doctoral position - Recruitment No 42/2026
Listed on 2026-08-03
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Research/Development
Research Scientist, Postdoctoral Research Fellow, Biomedical Science
Institute of Physical Chemistry, Polish Academy of Sciences
Organisation/Company Institute of Physical Chemistry, Polish Academy of Sciences Department Team 13:
Physical chemistry of complex systems Research Field Physics >
Condensed matter properties Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Final date to receive applications 24 Aug 2026 - 12:00 (Europe/Warsaw) Country Poland Type of Contract Temporary Job Status Full-time Hours Per Week 40 Offer Starting Date 1 Oct 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Reference Number 42/2026 Is the Job related to staff position within a Research Infrastructure?
No
Post-doc position available in the Institute of Physical Chemistry PAS within National Science Center (NSC) OPUS 30 Project no.
2025/59/B/ST3/01980, entitled “Multiscale Modelling of Metabolite Channeling:
Physiological Insights and Optimization of Enzyme Cascades”.
Enzyme-catalysed reactions are among the most ubiquitous and elegant chemical processes in nature. They sustain virtually all life functions and underpin numerous biotechnological applications. In living systems, enzymes are often organised into reaction cascades, where multiple enzymes act sequentially to convert substrates into products, and are frequently clustered within microcompartments and membrane-bound organelles. Such organisation can enhance catalytic efficiency, suppress undesirable side reactions, and regulate metabolic fluxes.
Inspired by these natural systems, synthetic enzyme assemblies and nanocages have been developed for applications ranging from biocatalysis to nanomedicine. However, the physical principles governing their performance remain poorly understood, largely because enzymatic cascades span spatial and temporal scales that are difficult to capture within a single computational framework.
This project aims to develop a novel multiscale simulation framework for modelling enzymatic processes across molecular, cellular, and biotechnological scales. The framework will be used to establish predictive design principles for optimising synthetic enzyme cascades and nanocage-based biocatalytic systems. The project will be carried out in collaboration with Forschungszentrum Jülich and Queen’s University Belfast, which will provide experimental validation and characterisation
RequirementsResearch Field Physics >
Condensed matter properties Education Level PhD or equivalent
Research Field Other Education Level PhD or equivalent
Skills/Qualifications
The successful candidate will develop a multiscale simulation framework for enzymatic systems and apply it to study how enzyme proximity, macromolecular crowding, and nanocaging regulate cascade efficiency. They will contribute to scientific publications and disseminate results at national and international conferences.
Specific Requirementsin accordance with the National Science Centre’s approval to change the condition regarding the number of years after obtaining the doctoral degree.
- their PhD degree has been conferred by an institution other than the one employing them at this position. Otherwise, they must have completed a continuous and evidenced research fellowship of at least 9 months during their studies at the doctoral school, doctoral studies or after being conferred their PhD degree at another institution than the participating entity for the project and outside the country in which their PhD degree was conferred ;
- they will be employed for a period of at least 6 months;
- when the remuneration is paid, they will be receiving no other remuneration paid from the funds granted to research projects under NCN calls under the heading of direct costs;
- when the remuneration is…
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