PhD student in Prof. Nishit Goradia group (Sonata Bis 15 - project) 08/2026
Listed on 2026-08-14
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Research/Development
Postdoctoral Research Fellow, Research Scientist, Biomedical Science, Genetics / Genomics
The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences
Organisation/Company The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences Research Field Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Positions PhD Positions Final date to receive applications 30 Sep 2026 - 22:56 (Europe/Warsaw) Country Poland Type of Contract Temporary Job Status Full-time Hours Per Week 40 Offer Starting Date 1 Nov 2026 Is the job funded through the EU Research Framework Programme?
Not funded by a EU programme Reference Number PHD Student__NG_08/2026 Is the Job related to staff position within a Research Infrastructure? No
Offer Description
The International Institute of Molecular Mechanisms and Machines (IMol PAS) is an international research institute in Warsaw working at the intersection of biology, biotechnology, bioinformatics, biophysics, and medicine. We are recruiting a PhD student to join the newly established Goradia Lab and work on the SONATA Bis-15 project funded by the National Science Centre (NCN).
Currently, IMol is seeking a candidate for the position of PhD student in Warsaw, Poland, to implement the project Molecular Mechanism of CtBP corepressor activity inactivation by RAI2-induced CtBP polymerization , funded by the National Science Centre.
About the Goradia Lab
The Goradia Lab investigates how higher-order protein assemblies regulate transcription, chromatin organization, and cell fate. We combine molecular and cellular biology with biochemistry, quantitative imaging, and functional genomics to uncover fundamental mechanisms of gene regulation and their dysregulation in cancer. Our research seeks to understand how the spatial organization of transcriptional regulators shapes gene expression and cell identity.
Project title: Molecular Mechanism of CtBP corepressor activity inactivation by RAI2-induced CtBP polymerization
Research Project
About the Project
How transcriptional corepressors organize within the nucleus to regulate gene expression remains one of the fundamental unanswered questions in molecular biology. Our recent work, published in Nature Communications (2024), uncovered a previously unrecognized mechanism in which the tumour suppressor Retinoic Acid-Induced 2 (RAI2) induces higher-order polymerization of the transcriptional corepressor Carboxy-terminal binding protein (CtBP), driving the formation of nuclear assemblies that modulate transcriptional repression.
This discovery provides the conceptual and experimental foundation for the SONATA Bis project and raises fundamental questions about how supramolecular protein assemblies regulate gene expression and cell identity.
Building on this discovery, the SONATA Bis project aims to uncover the molecular mechanisms by which RAI2-induced CtBP polymerization modulates CtBP-mediated transcriptional repression and reorganizes transcriptional corepressor complexes. By integrating molecular biology, cell biology, quantitative microscopy, biochemistry, proteomics, and functional genomics, we seek to understand how higher-order protein assemblies regulate gene expression in mammalian cells and how disruption of these mechanisms contributes to cancer.
The SONATA Bis project encompasses three interconnected research directions:
- Determine how RAI2-induced polymerization remodels CtBP-containing transcriptional corepressor complexes.
- Define the spatial organization and dynamics of CtBP polymer assemblies within the cell nucleus.
- Determine how CtBP polymerization influences chromatin regulation and transcriptional programs.
Your Role
The PhD student will develop an independent research project within the broader SONATA Bis programme, focusing on the formation, spatial organization, and molecular properties of RAI2-induced CtBP assemblies. Working closely with the postdoctoral researcher and collaborators, the student will combine mammalian cell biology, molecular biology, quantitative fluorescence imaging, and biochemistry to uncover how CtBP polymerization regulates transcriptional repression.
The project will involve generating and…
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