Postdoc in Prof. Nishit Goradia group (Sonata Bis 15 - project) 08/2026
Listed on 2026-08-14
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Research/Development
Postdoctoral Research Fellow, Research Scientist, Biomedical Science, Genetics / Genomics
The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences
Organisation/Company The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences Research Field Biological sciences » Biology Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Final date to receive applications 30 Nov 2026 - 23:59 (Europe/Warsaw) Country Poland Type of Contract Temporary Job Status Full-time Hours Per Week 40 Offer Starting Date 1 Dec 2026 Is the job funded through the EU Research Framework Programme?
Not funded by a EU programme Reference Number Postdoc__NG_08/2026 Is the Job related to staff position within a Research Infrastructure? No
Offer Description
The International Institute of Molecular Mechanisms and Machines (IMol PAS) is an international research institute in Warsaw, Poland, conducting interdisciplinary research at the interface of molecular biology, biotechnology, biophysics, bioinformatics, chemistry, and medicine.
Applications are invited for a Postdoctoral Researcher position in the newly established Goradia Lab to work on the SONATA Bis-15 project funded by the National Science Centre (NCN), Poland.
The successful candidate will join an ambitious research programme investigating the molecular mechanisms by which higher-order protein assemblies regulate transcriptional repression and chromatin organization in mammalian cells.
Project
Title:
Molecular Mechanism of CtBP corepressor activity inactivation by RAI2-induced CtBP polymerization
About the Lab: The Goradia Lab investigates how higher-order protein assemblies regulate transcription, chromatin organization, and cell fate. Our research combines molecular and cellular biology, quantitative fluorescence imaging, protein biochemistry, proteomics, and functional genomics to uncover fundamental mechanisms governing transcriptional regulation and their dysregulation in cancer.
Our long-term goal is to understand how the spatial organization of transcriptional regulators influences gene expression, cellular plasticity, and disease progression. By integrating mechanistic biology with systems-level approaches, we aim to reveal fundamental principles of gene regulation that extend beyond the CtBP transcriptional corepressor system.
As a newly established laboratory at IMol PAS, we offer an exciting opportunity to help build an internationally connected research programme within a highly collaborative scientific environment.
Research Project
About the Project
Transcriptional corepressors are essential regulators of gene expression, yet the molecular mechanisms by which they organize within the nucleus to control transcription remain poorly understood.
Our recent work, published in Nature Communications (2024), uncovered a previously unrecognized mechanism in which the tumour suppressor RAI2 induces higher-order polymerization of the transcriptional corepressor CtBP
, resulting in the formation of supramolecular nuclear assemblies that relieve CtBP-mediated transcriptional repression. This discovery establishes an entirely new paradigm for understanding how multivalent protein interactions regulate transcriptional corepressor activity and provides the conceptual foundation for the SONATA Bis project.
Building upon this discovery, the SONATA Bis project seeks to define the molecular mechanisms by which RAI2-induced CtBP polymerization remodels transcriptional corepressor complexes, reorganises chromatin-associated regulatory networks, and ultimately influences gene expression.
To address these questions, the project integrates molecular biology, mammalian cell biology, quantitative fluorescence microscopy, protein biochemistry, quantitative proteomics, and functional genomics to investigate transcriptional regulation across multiple spatial and molecular scales.
The project encompasses three interconnected research directions:
- Determine how RAI2-induced polymerization remodels CtBP-containing transcriptional corepressor complexes.
- Define the spatial organization and dynamics of CtBP polymer assemblies within the cell nucleus.
- Determine how CtBP polymerization influences chromatin regulation and transcriptional programs.
Together, these studies will establish a comprehensive mechanistic framework describing how higher-order protein assemblies regulate transcription and will provide new insights into transcriptional dysregulation in cancer.
Your Role
The successful candidate will play a leading scientific role in the SONATA Bis project, driving the mechanistic and functional genomics components while working closely with the Principal Investigator to shape the scientific direction of the newly established Goradia Lab.
The project will involve designing and executing experiments using mammalian cell biology, CRISPR/Cas9 genome engineering, molecular biology, protein biochemistry, quantitative proteomics, and functional genomics to investigate how RAI2-induced CtBP polymerization regulates…
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