Cryo-Electron Tomography; cryo-ET Scientist

The Stowers Institute for Medical Research seeks a Cryo‑Electron Tomography (cryo‑ET) scientist to support and expand our growing in situ structural biology and integrative imaging efforts. This senior‑level position within the Technology Center will play an active role in developing and executing cryo‑ET projects, enabling visualization and structural interpretation of molecular assemblies directly within cells and tissues.

Working closely with Stowers investigators, the successful candidate will lead collaborative cryo‑ET projects across diverse biological systems. This is a highly hands‑on position focused on advancing workflows from sample preparation and data collection through analysis and structural interpretation, while contributing to the Institute’s strategic expansion into cryo‑ET and integrative structural biology.

• Lead and execute cryo‑ET projects in collaboration with investigators and technology center scientists.
• Develop and optimize workflows for in situ cryo‑ET, including sample preparation, tilt‑series acquisition, tomographic reconstruction, and subtomogram averaging.
• Contribute to integrative structural workflows combining cryo‑ET with complementary approaches such as Alpha Fold‑based structural prediction, crosslinking mass spectrometry (XL‑MS), and molecular simulations or integrative modeling.
• Provide scientific guidance and training to researchers using cryo‑ET approaches.
• Maintain strong communication across multidisciplinary teams to ensure successful project outcomes.
• Travel to collaborating facilities for cryo workflow and/or data acquisition is required for this position.

• Ph.D. in structural biology, biophysics, cell biology, biochemistry, or related field; postdoctoral experience preferred.
• Hands‑on experience in cryo‑EM, with demonstrated expertise in cryo‑ET workflows.
• Experience with cryo‑ET data processing software and analysis pipelines.
• Strong organizational and collaborative skills with experience working on multidisciplinary projects.
• Preferred but not required: experience or interest in integrative structural biology approaches such as AI based structural prediction, and/or molecular simulations.

Please submit a current CV and cover letter that includes your research experience as well as a short summary of interests to careers or to Administration Department, Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110.