Neonatal-Perinatal Medicine, Neonatal Research Faculty (MD, PhD, or MD​/PhD

Neonatal Research Faculty (MD, PhD or MD/PhD)

Division of Neonatology/Neonatal Diseases Research Program/Childrens Mercy Kansas City

The Division of Neonatology (Director: Dr. Steve Olsen) and the Neonatal Diseases Research Program (Director: Dr. Venkatesh Sampath), along with the Childrens Mercy Research Institute (CMRI Director: Dr. Tom Curran) announce a national search for an MD, PhD, or MD/PhD scientist to conduct translational or basic science research in the areas of neonatal lung or gut injury. MD or PhD scientists studying the molecular mechanisms of neonatal diseases such as bronchopulmonary dysplasia, necrotizing enterocolitis, genome-microbiome interactions, and the developing gut-brain axis are encouraged to apply.

The Division of Neonatology, the Neonatal Diseases Research Program, and the CMRI are in an exciting period of research growth and expansion.

The Neonatal Diseases Research Program (NDRP) is located in the new state-of-the-art, nine floor, CMRI research building in 2020 (375,000 total sq. feet). The new CMRI building houses the majority of CM investigators pursuing translational research, and is equipped with a full complement of research cores including genomics, flow cytometry, imaging, GMP biologics, and a rodent vivarium. The NDRP is housed on the 7th floor of CMRI research tower with adequate space for current personnel and future expansion.

It is anticipated that recruited personnel will be housed in proximity to our current lab.

The NDRP, which focuses broadly on the molecular mechanisms regulating endothelial and epithelial injury in the context of the developing lung and intestine, is funded by the NHLBI, the NIDDK, the NICHD, the March of Dimes, and several local foundations. The laboratory combines human genetic studies, cell-culture models, microbiome analyses, transgenic mouse models, novel therapeutics, and translational studies to investigate the inflammatory/developmental basis of neonatal diseases such as bronchopulmonary dysplasia, necrotizing enterocolitis, and rare infectious diseases.

The laboratory currently employs 6 full time PhD and masters level scientists. Junior faculty and clinical fellows from Neonatology and infectious disease participate in the NDRP. We advocate a culture of discovery, innovation, team science, diversity and excellence. Access to an active neonatal genomic biorepository established by Dr. Sampath, that houses de-identified DNA samples from phenotypically well-characterized preterm and term cohorts, is available.

Active collaborations with the Childrens Mercy Center for Pediatric Genomic Medicine (Director: Dr. Tomi Pastinen) are underway for advanced sequencing-based discovery of human genetic loci affecting several neonatal diseases and include the use of single-cell sequencing to characterize cellular phenotypic alterations in pre-clinical models. The Genomic Answers for Kids Study (GAKS), pioneered by the Genome Center, is a one of a kind study characterizing the genetic basis of rare/undiagnosed diseases using advanced sequencing/epigenetic profiling.

Synergies can be realized with the Center for Perinatal Research (Director: Dr. Michael Soares), which utilizes rodent models to examine placental development and function in health and disease. Dr. Robert Lanes (Physician in Chief, CMKC) laboratory, that focuses on perinatal programming of adult onset disease, is in close physical proximity to the NDRP, and provides another venue for collaboration. The Fetal Health Center, which is dedicated to management of babies diagnosed with complex pathology/diseases, and includes a tissue biorepository, offers opportunities for research and collaboration.

Other major centers of research excellence within the CMRI are Population Health, Precision Therapeutics, and Innovation in Healthcare Delivery.

We are seeking a highly motivated individual, who thrives in a collaborative team science environment, with a demonstrated ability to lead research. The ideal candidate will have an emerging or established independent research program, with a track record of quality publications as well as K, R21, R01, or equivalent, extramural funding. We welcome candidates with PhD, MD/PhD, MD, or equivalent degrees, pursuing research interests that synergize with current and future work in the NDRP.

Expertise in endothelial signaling, immunity, animal model systems, metabolomics, bioinformatics, and stem cell biology as it pertains to developing lung/gut injury or other NDRP interests, are of particular interest. Candidates with an MD, or equivalent, must be board certified by the American Board of Pediatrics in Neonatal-Perinatal Medicine, and be eligible for a Kansas and Missouri Medical license. Appointment will be at the Assistant, Associate or Full Professor level.

Institutional commitment in the form of a start-up package and protected time is available and will be commensurate with track record and experience.

The Division of Neonatology at…