Sr Scientist – Biomarker Method Development

Performing critical work that impacts our industry and our world's health while problem solving and innovating in the field - that is what Sr. Scientists at KCAS Bio get to do every day. If that gets you excited too, then maybe working as a Sr. Scientist at KCAS Bio is the role for you.

• Lead the design, development, optimization, and troubleshooting of ligand binding assays with a primary focus on biomarker method development
• Design experiments and independently evaluate assay performance to establish robust and scientifically appropriate methods
• Develop and optimize assay conditions, reagents, controls, and workflows to address complex biomarker method development challenges
• Apply strong scientific judgment to evaluate assay performance characteristics, including precision, accuracy, sensitivity, selectivity, specificity, and robustness
• Troubleshoot complex assay performance issues, identify root causes, and develop scientifically sound solutions
• Support method qualification, validation, and transfer activities as appropriate for the intended use of the assay
• Contribute scientific expertise to PK and immunogenicity/ADA method development activities as applicable
• Act as a technical expert and scientific resource for biomarker assay development, performance, troubleshooting, and problem solving
• Act as lead scientist, help design experiments, and provide work instructions and technical training to more junior scientific staff
• Review and interpret scientific data and communicate findings, recommendations, and potential risks to internal teams and clients
• Partner with clients and internal stakeholders to understand scientific objectives and translate those needs into appropriate bioanalytical strategies
• Prepare and review study documentation, data summaries, protocols, and reports as appropriate
• Work collaboratively with Quality Assurance and scientific teams to ensure activities are conducted in accordance with applicable protocols, SOPs, regulatory requirements, and quality standards
• Maintain knowledge of current scientific, technological, and regulatory developments relevant to biomarkers and ligand binding assay development
• Be responsible for timeline adherence and communication of status to management as required
• Perform all aspects of the job in a way that supports company brand and supports company mission, vision, and values

• Bachelor's, Master's, or PhD in Biology, Biochemistry, Immunology, or related scientific field with at least 5 years of experience in a bioanalytical laboratory environment
• Demonstrated depth of experience in biomarker method development, including the development, optimization, and troubleshooting of biomarker assays
• Strong hands-on experience with ligand binding assays (LBA), including ELISA, MSD, or similar immunoassay platforms
• Demonstrated ability to independently design experiments, evaluate assay performance, troubleshoot complex technical challenges, and optimize assay conditions
• Strong understanding of assay performance characteristics, including precision, accuracy, sensitivity, selectivity, specificity, and robustness
• Experience with method development, qualification, and/or validation in a regulated bioanalytical, pharmaceutical, biotechnology, or CRO environment
• Strong scientific judgment and the ability to interpret complex data and make recommendations based on experimental outcomes
• Experience working within established regulatory and quality frameworks applicable to bioanalytical method development
• Strong written and verbal communication skills with the ability to communicate complex scientific information to internal and external stakeholders
• Ability to provide technical…