Research Fellow; Genome Editing - Directed Evolution

Research Fellow (Genome Editing - Directed Evolution)

Posting

Start Date:

14/10/2025

We are seeking a talented postdoctoral fellow to join the Genome Re-Innova Tion-Lab ((Use the "Apply for this Job" box below).), part of the Synthetic Biology Translational Research Programme (TRP) at the National University of Singapore, Yong Loo Lin School of Medicine. The Synthetic Biology TRP focuses on developing novel genome editing tools by engineering CRISPR systems, enhancing their function through fusion with other enzymes, and applying high-throughput screening strategies to isolate improved variants.

The Research Fellow (RF) will play a key role in implementing directed evolution experiments using phage-based platforms to evolve genome editing proteins with enhanced properties. Appointments will initially be made on a 1-year contract, with the possibility of extension. PhD holders with no prior experience in phage-based evolution systems are welcome to apply and will receive necessary training.

• Design and perform phage-based directed evolution experiments to engineer novel genome editing proteins.
• Rationally identify protein engineering sites and generate diverse mutant libraries.
• Conduct functional assays in mammalian cell lines and primary cells to evaluate genome editing efficiency.
• Analyze editing outcomes using Next Generation Sequencing (NGS) and other molecular tools.
• Mentor research assistants, graduate, and undergraduate students.
• Collaborate closely with the Principal Investigator and team members in experimental planning and troubleshooting.
• Assist in any other duties as delegated by the Principal Investigator and group leaders.

• A PhD in Biotechnology, Biological Sciences, Biochemistry, or a related field.
• Hands‑on experience in molecular cloning, library construction, and microbial genetics.
• Familiarity with or interest in applying phage systems for directed protein evolution.
• Ability to work independently and collaboratively, with strong critical thinking and problem‑solving skills.
• Experience with NGS‑based assays for genome editing is a plus.
• A track record of international publications.

Remuneration will be commensurate to the candidate's qualifications and experience.

Ms Suhana Sulaiman
, at suhana_s.sg

Formal application: Please submit your application, indicating job reference number and current/expected salary, supported by a detailed CV (including personal particulars, academic and employment history, complete list of publications/oral presentations and full contacts of 3 referees). Only shortlisted candidates will be notified.

Location:

Kent Ridge Campus

Organization:
Yong Loo Lin School of Medicine

Department:
Dean-Med-Synthetic Biology Translational Research Programme

Employee Referral Eligible:
No

Job requisition