SVP Late Clinical Development

San Diego, CA, South San Francisco, CA, or remote

Erascais a clinical-stage precision oncology company focused on discovering, developing and commercializing medicines for the benefit of patients with cancer. Our programs take novel approaches to shutting down one of cancer’s most commonly mutated signaling cascades, the RAS/MAPK pathway, which affects approximately 5.5 million lives each year worldwide. The name “Erasca” has an important embedded meaning: it is a contraction of our audacious hope to “erase cancer” that drives our mission and everything we do on behalf of patients with cancer.

Reporting to the Chief Medical Officer, the SVP Late Clinical Development will provide medical leadership and oversight of late-stage clinical trials and collaborate with the CMO across the Erasca portfolio. In addition, the SVP will be a hands–on drug developer and will serve as clinical lead and/or medical monitor on programs or studies. A key area of focus will be the design and execution of multiple registration enabling trials in solid tumor indications.

• Provide medical direction and high-quality scientific and clinical knowledge to guide the strategy and execution oflate-stageclinicalprogramsandcontribute to clinical decision making across the Erascaportfolio.
  
  Participate inbuildingandmaintaininga culture of rigorous data-driven decision making.
• Lead late clinical development function, directly and through reports.
• Responsibilities will include clinical development strategy, protocol development, registrational strategy, KOL and academic site interactions, competitive landscape diligence, presentation of data, and other clinical deliverables.
• Serve as Medical lead on clinical programs and r epresent Clinical Development on program teams.
• Design and implement novel and efficient registration enabling clinical trialstoassessappropriate endpoints.
• Responsible for leading clinical studysubteams,monitoring overall study integrity, and review, interpretation,and communication of safety and efficacy data.
• Contribute to regulatory filings including authoring clinical sections for NDAs and other related documents.
• Partner with Drug Safety to assess the safety profile of compounds.
• Write medical aspects of core study and regulatory documents including clinical research plans, protocols, investigator brochures, clinical studyreportsand regulatory submissions.
• Contribute to the development and review of scientific publications; author manuscripts and collaborate with cross-functional colleagues and thought leaders to meet publication plan objectives.
• Present at scientific, medical,and regulatory meetings.
• Maintaina high levelof clinical and scientificexpertiseby reviewing literature, attending medicalorscientific meetings,and through personalexchangewiththought leaders, investigators,and internal stakeholders and partners.
• Participate in due diligence or other business development activities.
• Recruit,retain, and develop high-functioning late clinical development team.
• Establish, develop,andmaintainrelationships across Erasca, particularly with partners and stakeholders in Research and Development.
• Perform all duties in keeping with the Company’s core values,policies and all applicable regulations.

• M.D.degreeor equivalent, with subspecialtyfellowshiptraining and board certification or eligibility in Oncology or Oncology/Hematology.
• 12+years ofoncologyclinical trial anddrug development experience,including extensive experience in the pharmaceutical or biotechnology industry.
  
  The ideal candidate will bringa combination of clinical practice, academic clinical trials,and industry experience,withbothlarge and small companyexperiencea plus.
• Direct management of…