Senior Director, Dosimetry and Radiobiology Physicist

Location: Northern

At Rayze Bio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, Rayze Bio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer.

Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients. Learn more about Rayze Bio:
The Sr. Director, Radiopharmaceutical Dosimetry & Radiobiology will be responsible for applying their deep expertise in radiopharmaceutical therapy (RPT) dosimetry, Monte Carlo-based dose calculation, and radio biology to drive innovation and ensure the highest standards in both preclinical and clinical programs. The Sr. Director will join the Nuclear Oncology Physics and Radiation Biophysics team in leading and coordinating internal dosimetry activities across multidisciplinary teams, overseeing translational dosimetry analysis from discovery through clinical development, connecting absorbed dose to biological response, and managing collaborations with internal stakeholders, external vendors, academic partners, and scientific consortia.

The ideal candidate will execute conventional RPT dosimetry approaches with ease, pioneer patient-level and multi-scale dose calculation methods, contribute to protocol, standards, and strategy development, and provide technical leadership, mentorship, and training, all while championing quality practices and regulatory compliance in the adoption of novel radioisotopes and modeling approaches, including for alpha-emitting radiotherapeutics.
** Job Responsibilities
** Essential duties and responsibilities include the following. Other duties may be assigned.
* Lead and coordinate all aspects of internal dosimetry, absorbed dose calculation, and dose–response analysis in the discovery and development of radiopharmaceutical imaging and/or therapeutic agents.
* Initiate, design, and execute dosimetry strategies for preclinical and clinical studies, including dosimetry protocol and workflow development, imaging-to-dose analysis plans, uncertainty evaluation, and clinical trial reporting.
* Direct advanced, patient-level dosimetry methods derived from quantitative imaging modalities (e.g., PET, SPECT, CT), including voxel-level and Monte Carlo-based dose calculation, time-activity integration, pharmacokinetic and compartmental modeling, and translation of dosimetry from animal to human.
* Establish and champion multi-scale dosimetry approaches (organ, voxel, cellular, and sub-cellular) to characterize dose heterogeneity and biological effect, with particular emphasis on alpha-emitting radiotherapeutics.
* Integrate dosimetry with radiation biology by partnering with biology and translational teams to link absorbed dose to biological response, informing dose selection, combination strategies, and therapeutic window optimization.
* Oversee and optimize dosimetry data quality control, including standardization, calibration, validation against physical measurement, and quality assurance aligned with current industry guidelines, technical standards, and literature.
* Innovate and implement new dose calculation platforms and modeling approaches to enhance therapeutic efficacy and radiopharmaceutical development, including for novel radioisotopes (e.g., alpha-emitters).
* Evaluate, manage, and support relationships with dosimetry software vendors, CROs, external investigators, academic…