MES Technical Lead​/Systems Architect LP

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work, but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Lilly is building a new gene therapy manufacturing site (LP2) in Lebanon, Indiana. This role owns the Manufacturing Execution System (MES) end-to-end, from the Tulip application layer and Tulip Table data model, through Mule Soft integrations connecting SAP, QbDVision , and Lab Vantage , to the MQTT-based Unified Namespace driving real-time equipment communication. You will serve as both the technical authority over the platform’s architecture and the hands‑on engineer responsible for its ongoing design, build, and validation.

• Serve as Technical Lead/SME for LP2 MES architecture, design standards, and technical direction
• Design, build, and validate Tulip applications for GxP manufacturing workflows and electronic batch records
• Direct automation integrations with Automation Engineering (equipment commands, confirmations, process value subscriptions)
• Author/approve design specs ensuring compliance with ALCOA+ and 21 CFR Part 11
• Guide components through validated migration lifecycle (DEV → QA → Production)
• Participate in Change Control Board (CCB) and Service Now change management
• Partner with Manufacturing Operations, Automation Engineering, and Quality (BQA/CSQA)
• Mentor MES engineers; act as escalation point for complex issues
• Collaborate with MES Product Owner on ALM requirements/backlog
• Report system status and technical risk to site/IT leadership

• Bachelor's degree in IT, Software /Computer Engineering or related field
• 5+ years with MES or pharma manufacturing IT platforms, including system integration (middleware/ERP/PLM) and Computer System Validation (CSV) in GMP settings

• Modern software architecture and integration patterns
• Mule Soft/ Anypoint , Data Weave for MES–ERP(SAP)–PLM integrations
• MQTT, Unified Namespace (UNS), OPC UA knowledge
• CSV experience:
  Validation/Test Plans, IQ/OQ/UAT, design specs under 21 CFR Part 11/ALCOA+
• Understanding of eBRs , non-terminal record controls, e-signatures
• Git/Git Hub, Git Hub Actions, MUnit, ALM/Jira
• Familiarity with MABL and Service Now
• Strong cross-functional communication and problem-solving skills

• Position Location:
  
  Lebanon, Indiana, with potential travel to other U.S. and global Lilly sites as required.
• Travel Percentage (%):
• Shift Information:
  Role is Monday through Friday and based on‑site. Must be flexible in providing support to accommodate production schedules, batch execution windows, and change control activities. Occasional extended hours and/or off‑hour support may be required .

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (  ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

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