Sr Scientist - Biopharmaceutics

Company Description

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, Facebook, Instagram, X and You Tube.

The Molecular Profiling and Drug Delivery (MPDD) function within the Small Molecule CMC organization is accountable for a broad range of deliverables across various stages of drug discovery and development. During lead optimization and through candidate selection, MPDD scientists utilize state of the art automation and computational tools supported by expertise in biopharmaceutics, drug delivery, and solid-state chemistry to collaboratively progress candidates with higher probability of success into development and advise clinical formulation strategy.

From candidate selection through clinical proof of concept and product launch, MPDD scientists work in cross functional teams to identify the commercial solid form of the active pharmaceutical ingredient (API) and establish structure-property-performance correlations to help deliver robust commercial processes and align control strategies across drug substance and product. They also transition drug substance isolation processes and relevant physical characterization methods to commercial manufacturing sites and work within teams to ensure successful regulatory submissions.

Drug Delivery scientists within Abb Vie's MPDD organization work collaboratively with other functions within Development Sciences and Discovery to conduct develop ability assessment to select molecules with higher probability of success for clinical development and eventual commercialization. This includes profiling of physicochemical properties, development of preclinical formulations, identifying solutions to in vivo absorption challenges, and advancement of novel drug delivery strategies across multiple routes of administration that are aligned with program target product profiles and downstream partners.

Modalities of interest include traditional small molecules as well as complex chemically synthesized modalities such as PROTACs and peptides. In this role, you will work in cross-functional teams in matrixed environments and engage in multidisciplinary problem solving.

Job Description

Abb Vie's MPDD organization is seeking a highly motivated, talented, and creative scientist with expertise and experience in biopharmaceutics, pharmaceutical science, and drug delivery for a Senior Scientist I position. The primary role of this position is to serve as a biopharm project leader within MPDD to support discovery and early clinical programs and lead peptide oral delivery programs. This individual will lead CMC develop ability assessment for emerging molecules on peptide and small molecule pipeline programs.

This role will also entail contributing towards developing our drug delivery capabilities with a focus on complex chemically synthesized modalities. This person will be working collaboratively with discovery and development partners across disciplines to improve delivery of these modalities and advance molecules to clinical development with improved develop ability profiles. The desired candidate will have a strong background and hand-on experience in the areas of physicochemical and/or biophysical properties and their impact on develop ability, preclinical and/or clinical formulation, biopharmaceutics, and drug delivery concepts relevant to small molecules and peptides

• Senior Scientist I typically requires Bachelors, Masters, or Ph.D. with 10+ (B.S.), 8+ (M.S.), and 1-3 (Ph.D.) years of experience in pharmaceutical or related industry. Preferred educational backgrounds include but are not restricted to Pharmaceutical Sciences, Pharmaceutical Engineering, Chemical/ Biomedical Engineering, and Materials Science.
• Fundamental understanding of biopharmaceutics as it relates to drug absorption across routes of administration including biorelevant dissolution testing, ex vivo permeability assessment, and peptide aggregation.
• Familiarity and preferred hands-on experience in physicochemical property assessment related to understanding CMC develop ability profile and…