Scientist​/Sr. Scientist Yeast Surface Dislay

Location: Northern

Scientist/Sr. Scientist Yeast Surface Dislay Skip to main content

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Cookie notice - Zealand Pharma#Scientist/Sr. Scientist Yeast Surface Dislay page is loaded## Scientist/Sr. Scientist Yeast Surface Dislay Apply locations:
Cambridge, MA, UStime type:
Full time posted on:
Posted Yesterday job requisition :
JR365

Does it excite you to work at the frontier of antibody and binder discovery, and do you have hands-on experience with yeast surface display technology? If this sounds like you, and you are ready to help build a new discovery platform from the ground up, then you could be our new colleague.
** Your new position
** As a Scientist or Senior Scientist in Yeast Surface Display, you will play a central scientific role in our new Molecular Platform Development organization, driving antibody, VHH, and other mini-protein and binder discovery through yeast display technology. You will help build and operate a modern, high-throughput display platform at the inception of our new Cambridge, MA research center. This role suits a scientist with strong technical expertise across the full yeast surface display workflow, scientific curiosity, and a desire to grow in scope and responsibility.
*** We offer exciting responsibilities:
**** Execute the full yeast surface display workflow, from library construction and transformation through magnetic bead and FACS-based selections, generating antibody, VHH, affibody, constrained peptide, and other mini-protein binders
* Conduct display selections against complex and challenging targets, including GPCRs, other multi-pass membrane proteins, and receptor complexes
* Design and execute affinity maturation and selection strategies to improve binder affinity, specificity, and develop ability
* Apply next-generation sequencing (NGS) to track library diversity, monitor selection enrichment, and identify lead clones from display campaigns
* Contribute to the development and application of yeast surface display capabilities within Molecular Platform Development
* Partner closely with Mass Spectrometry, Biophysics, and Pharmaceutical Development colleagues to validate hit quality, sequence fidelity, and develop ability early in selection campaigns
** Your profile
** You bring strong technical expertise across the full yeast surface display workflow, along with scientific curiosity and sound judgment. You thrive in a collaborative, multidisciplinary environment and are motivated to help shape a new platform and research center from an early stage. You communicate scientific data and concepts clearly and work effectively across cross-functional project teams.
* PhD in Protein Engineering, Immunology, Molecular Biology, Biochemistry, or a related field preferred (postdoctoral training preferred); candidates with a BS/MS and significantly more relevant industry experience will also be considered
* 2+ years of relevant post-degree experience in yeast surface display or related antibody/protein discovery technologies (Scientist); 4+ years (Senior Scientist)
* Experience with antibody, VHH, affibody, constrained peptide, and other mini-protein or binder formats
* Experience conducting display selections against complex targets, such as GPCRs, other multi-pass membrane proteins, or receptor complexes, is a plus
* Experience applying next-generation sequencing (NGS) to analyze display library diversity and selection enrichment; familiarity with associated bioinformatics is a plus
* Familiarity with phage display or other in vitro/in vivo display technologies, and with protein expression, purification, and analytical characterization sufficient to support binder validation
** Your new team
** You will join Molecular Platform Development, a new…