Research Scientist in Single B-Cell Sequencing & Antibody Discovery at Elanco

Elanco seeks a highly motivated, innovative Research Scientist to join its Discovery Research team. This position focuses on advanced single B-cell sequencing, immune library construction and antibody discovery to identify high-quality therapeutic antibody candidates for animal health applications.

The successful candidate will contribute to capturing and isolating natural immune repertoires from diverse animal species using comprehensive molecular biology and next-generation sequencing workflows.

Elanco Animal Health is a global leader in animal health, developing innovative products and services to prevent and treat disease in farm animals and companion animals.

• Lead and execute end-to-end single B-cell antibody discovery workflows.
• Process immune cells and perform FACS-based isolation of antigen-specific B cells.
• Perform single-cell sequencing and high-throughput molecular rescue of paired antibody variable-region sequences.
• Contribute to identification and characterization of promising antibody candidates.
• Design and construct high-diversity immune libraries from immunized animals.
• Develop and implement NGS workflows for library characterization.
• Monitor library diversity and track selection dynamics across display platforms.
• Develop and manage panning and selection strategies using phage display or yeast display.
• Identify rare, high-affinity antibody binders from diverse immune repertoires.
• Evaluate and optimize display-based antibody discovery workflows.
• Perform high-throughput RT-PCR and nested PCR.
• Rescue heavy- and light-chain variable regions from individual B cells.
• Apply specialized molecular cloning techniques for antibody discovery workflows.
• Collaborate with bioinformatics teams to integrate large-scale NGS datasets.
• Analyze antibody repertoires and identify novel antibody lineages.
• Evaluate repertoire convergence and selection dynamics.
• Represent the antibody discovery group in multidisciplinary project teams.
• Communicate discovery strategies, experimental results and technical recommendations to stakeholders.
• Collaborate with scientists across discovery research and related functions.
• Maintain accurate electronic laboratory notebooks and research documentation.
• Present technical findings at internal research forums and stakeholder meetings.
• Contribute to scientific decision-making through clear interpretation of discovery data.
• Evaluate emerging antibody discovery technologies.
• Implement improved workflows to increase throughput, repertoire diversity and functional screening capabilities.
• Contribute to reducing discovery timelines and improving biologics development strategies.

• PhD in Immunology, Molecular Biology, Biotechnology or a closely related discipline.
• 0-3 years of relevant industrial experience in biologics discovery.
• Candidates should have hands‑on experience in:
  Single B-cell sequencing workflows,
• High-speed flow cytometry/FACS
• NGS library preparation
• Immune library construction
• Phage display or yeast display technologies
• High-throughput PCR
• Molecular cloning
• Antibody discovery workflows
• NGS data analysis and interpretation.