Sr. Scientist

*** Senior Scientist – Bioanalytical Method Development LC-MS/MS
**** The Senior Method Development Scientist will perform method development utilizing contemporary mass spectrometry techniques (LC-MS/MS & HRMS) for large and small molecules (proteins, antibodies, ADCs oligonucleotides, etc.). The senior method development scientist will be a member of the DMPK team and will serve as a subject matter expert for new proposals, evaluating feasibility of LC-MS/MS method development, and troubleshooting challenging methods across a wide variety of species and matrices.
** Join us in embracing research and science to impact the health and well-being of people all over the world.
*** Essential Duties and Responsibilities
*** Develop highly sensitive LC-MS/MS and HRMS methods for large (oligonucleotides, proteins, antibodies, ADCs, biomarkers, etc) and small molecules in biological matrices.
* Utilize and interpret scientific theories, concepts, techniques in bioanalytical and mass spectrometry studies and accepts leadership role in developing novel scientific approaches
* Coordinate, facilitate, and implement intercompany method transfers and implementation of incoming transfers from clients.
* Communicate project timelines, status, and data to Principal Investigators, Project Management, and clients effectively addressing any issues that may arise.
* Ability to coordinate and execute on multiple projects simultaneously and responsive to unscheduled deadlines and client needs.
* Demonstrate an understanding of Best Practices, SOPs and Good Laboratory Practice Regulations (21 CFR, Part 58) as these relate to study-specific services provided, this job description, and general facility operations.
* Training and mentoring junior scientists within and across departments
* Collaborate with leadership on long-range planning and strategy for departmental growth
* Performs other duties as assigned.
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* Skills and Abilities

*** Experience, skills, and abilities must include knowledge of contemporary bioanalytical techniques, including wet chemistry separations, liquid chromatography, and mass spectrometric analysis (LC-MS/MS, HRMS), instrument operation, maintenance, and data processing.
* Proven track record of method development for large and small molecules
* Ability to incorporate software in the maintenance of databases to collate and catalog records and inventory.
* Working knowledge of laboratory software, system software, and Microsoft applications
* Independence in the laboratory and data work-up phases of research.
* A working knowledge and awareness of general laboratory procedures.
* Good written and oral communication skills.
* Ability to adhere to all safety regulations and procedures.
** Education and Experience
*** PhD in Organic Chemistry, Biochemistry, Analytical Chemistry or related discipline with 2+ years of industrial bioanalytical experience following Post Doctoral training
* M.Sc. in a discipline previously described with 5+ years direct industrial bioanalytical experience
* Candidates possessing working knowledge of in vitro metabolism/biotransformation, Pharmacokinetic modeling, analysis, interpretation and simulation desirable
** Physical Activity and Working Conditions
*** Work is normally performed in a typical interior office work or laboratory environment
* Work environment involves exposure to potentially dangerous materials and situations that require following extensive safety precautions and may include use of protective equipment
* The noise level is usually moderate
* This position will frequently be involved with radiant/electrical energy, solvents, grease, oil, irritants, acids, bases, and other hazardous chemicals, electro-mechanical hazards, flammable materials and bio-hazards. Due to…