Research Associate, Research Scientist, Clinical Research

Case Western Reserve University:
School of Medicine (FAC/RA/RS):
School of Medicine - Main Campus (FAC/RA/RS):
Pharmacology (FAC/RA/RS) Location

Cleveland, OH

Sep 11, 2026

Date:
September 2026

Title:

Research Associate

Department:
Pharmacology

Location:

Wood Building, Room 341

POSITION OBJECTIVE

The von Lintig lab focuses on the role of vitamin A and carotenoids in the functioning and maintenance of the biology of different organ systems. The Research Associate will design and plan projects, oversee collaborations, supervise staff and students, manage mouse models, and fully execute research projects within the aims of the laboratory’s NIH grants, including the RO1 grant entitled ‘Molecular factors controlling vitamin A uptake homeostasis’.

The objectives of the research are to understand how vitamin A homeostasis is maintained and regulated as well as to study the consequences of its pathological failure in knockout mouse models for human disease states, including Dhsr3, Lrat, and Isx knockout mice. The Research Associate will utilize histology and imaging techniques such as spectral domain-optical coherence tomography (SD-OCT), scanning laser ophthalmoscopy (SLO), and electroretinography (ERG) to assess retina functioning and structure.

Additionally, the Research Associate will utilize general molecular biology, cell culture, and biochemistry techniques, including DNA/RNA isolation, PCR, RT-PCR, Western blotting, and immunohistochemistry in this research project. The Research Associate will keep the PI informed of progress of the research project and provide recommendations on experimental design and project plans. The Senior Research Associate will also present data and findings at lab and scientific meetings, seminars, etc.,

prepare manuscripts, and contribute preliminary data for grant proposals.

ESSENTIAL FUNCTIONS

1. Provide scientific oversight of all research projects related to the RO1 grant, including data collection and maintenance. Establish and manage the day-to-day priorities of the research staff. (10%)

2. With the principal investigator, establish goals and objectives for the efficient and timely completion of projects. Meet regularly with the principal investigator to review and set priorities, staff/student-related issues, and future research staff and planning (5%).

3. Coordinate experiments performed by other lab members, ensuring adequate resources, assisting with experimental design and analysis. Oversee progress of the research projects and provide regular progress reports to the PI; and provide input and recommendation to principal investigator regarding significant developments in research projects. Ensure the PI is informed about the results of lab members, and ensure the PI’s experimental strategy is explored by lab members and through independent experiments by the Senior Research Associate (5%).

4. Independently and with the principal investigator, design, plan, and execute research projects with the aim of to characterize the role of Dhsr3 in vitamin A homeostasis of the intestine and liver and the consequences of its pathological failure. Specifically, perform dietary intervention experiments and analyze the consequences for intestinal and hepatic health. Use imaging techniques such as immunohistochemistry, qRT-PCR, Western blotting, in these analyses.

Determine retinoid and carotenoid composition of the eyes by HPLC analysis and quantify the concentrations with authentic standard substances (25%).

5. Develop new techniques and protocols to advance research projects within the lab. Train lab members on new techniques (10%).

6. Mentor and train lab staff and graduate students; oversee research work and ensure pro jects are being completed…