Research Scientist​/Engineer ; NE S UAW Research

Research Scientist/Engineer 2 (NE S UAW Research) page is loaded## Research Scientist/Engineer 2 (NE S UAW Research) remote type:
No Teleworklocations:
Seattle, WAtime type:
Full time posted on:
Posted Todaytime left to apply:
End Date:
October 5, 2026 (13 days left to apply) job requisition
- ** Job Description
**** The Department of Pharmacology at the Wisedchaisri's Lab has an outstanding opportunity for Research Scientist/Engineer 2 to join their team.
** The Department of Pharmacology at the Wisedchaisri Lab investigates the structure and mechanism of voltage-gated ion channels, their interactions with drugs and neurotoxins, and the structural basis of human channelopathies caused by disease-associated mutations. We combine structural biology approaches, including X-ray crystallography and cryogenic electron microscopy (cryo-EM), with biochemistry and electrophysiology to perform comprehensive structural and functional studies of ion channels.

Our goal is to uncover fundamental mechanistic insights that advance our understanding of ion channel function in health and disease and enable the development of innovative therapeutic strategies.
** About this Opportunity:
** Report to Research Assistant Professor, this Research Scientist will conduct independent and collaborative research focused on the over-expression, purification, and structural characterization of insect and human voltage-gated sodium channels in complex with insecticides. The successful candidate will investigate the molecular mechanisms of insecticide action on sodium channels and characterize insecticide-sodium channel binding interactions. This position will contribute to advancing our understanding of the molecular basis of insecticide selectivity and efficacy.
*
* Key Responsibilities:

**** Laboratory Research (75%):
*** Perform molecular biology techniques, including PCR, DNA isolation, cloning, sequencing, and construct generation.
* Perform mammalian and insect cell culture, recombinant protein expression, protein purification, protein biochemistry, and ligand-binding assays.
* Perform cryo-EM experiments, including grid preparation, grid screening, data collection, image processing, and three-dimensional structure determination.
* Design, execute, and troubleshoot experiments to achieve research objectives.
* Manage research projects of moderate scope and evaluate the feasibility of experimental approaches.
* Develop, optimize, and implement new experimental procedures and improve existing protocols.
* Prepare and maintain laboratory reagents, solutions, and research materials.
* Assist with laboratory organization, equipment maintenance, and implementation of laboratory best practices.
* Train laboratory personnel in experimental techniques and standard operating procedures.
** Data Analysis and Scientific Communication (20%):
*** Maintain detailed and accurate experimental records.
* Analyze, interpret, and present experimental data.
* Present research findings at laboratory and sponsor meetings.
* Prepare publication-quality figures, datasets, and written materials for manuscripts, grant applications, reports, and scientific presentations.
** Training and Mentoring (5%):
*** Provide guidance, training, and technical direction to Research Scientist/Engineers, postdoctoral scholars, students, and other research personnel engaged in laboratory and research activities.
* Mentor junior laboratory members in experimental design, technical skills, data analysis, and scientific problem-solving.
*
* Required Qualifications:

** To be considered for this opportunity, your application must demonstrate that you meet both the minimum qualifications and additional qualifications listed below. Equivalent education and/or experience may substitute for minimum qualifications except when there are legal requirements, such as a license, certification, and/or registration.
*
* Minimum Qualifications:

*** Bachelor's degree in biology, biochemistry, molecular biology, or related field and two years of laboratory experience.
* Equivalent education and/or experience may substitute for minimum qualifications except when there are legal requirements, such as a license, certification, and/or registration.
*
* Additional Qualifications:

*** Extensive experience with molecular biology techniques.
* Extensive experience with recombinant protein expression in mammalian expression systems and protein purification using FPLC systems.
* Demonstrated expertise in high-resolution cryo-EM, including grid…