Principal Scientist, Antibody Discovery Innovation

Location: Northern

## Principal Scientist, Antibody Discovery Innovation Apply:
Not Applicable:
USA
- California
- South San Francisco (Grand Ave):
Full time:
Posted Today:
End Date:
October 31, 2026 (30+ days left to apply):
R418515
** Job Description
** We are on a quest for cures and are committed to be the world’s premier, most research-intensive biopharmaceutical company. Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines.  We are seeking an exceptional and experienced scientist in the role of Principal Scientist in the South San Francisco Discovery Biologics group.

The qualified candidate will be a scientist with a breadth and depth of expertise in immunization-based antibody discovery, including but not limited to expertise in adaptive immunity and B-cell biology, immunogen design, and experience with multiple hit finding platforms (e.g. high throughput microfluidics & NGS), in order to improve existing antibody discovery processes to help meet the needs for challenging targets and aggressive timelines.

They will work closely with other team members and groups throughout the organization to help manage, perform, and troubleshoot antibody discovery programs.  We recognize that the diversity in our team is our strength, and we are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in working with a diverse group of researchers to drive our core mission.

What you will do:

* Provide holistic leadership for in vivo antibody discovery strategies encompassing operations, innovation, and externalization
* Propose and lead technology development initiatives for in vivo de novo antibody discovery to increase candidate hit quality and decrease timelines
* Lead and participate in cross-functional discovery project teams in partnership with therapeutic area scientists
* As a member of the Antibody Generation leadership team, will work across groups within Discovery Biologics and with departments across Our Company’s enterprise to set and deliver on our strategic goals in pipeline advancement, scientific excellence, and talent development
* Foster a high-performance growth mindset culture of collaboration, engagement, self-accountability, and inclusion
* Stay abreast of external advancements in relevant scientific and technology fields
* Promote the external reputation of our company’s Discovery Biologics department  
*
* QUALIFICATIONS:

*
* *
* Education:

*
* * Ph.D. (with 8+ years) in biophysics, biochemistry, structural biology or related science discipline and relevant industry experience  
** Required

Experience and Skills:

*
* * Extensive experience in antibody drug discovery supporting therapeutic programs
* Depth of knowledge in adaptive immunity and B-cell biology
* Track record of driving scientific and platform innovations
* Experience leading therapeutic antibody discovery campaigns
* Track record of leading high-performance teams
* Established external reputation through publications, presentations, and/or scientific community engagement
* Excellent communication and collaboration skills
* Ability to manage multiple projects simultaneously  
** Preferred

Experience and Skills:

*
* * Ideal candidate will have experience in protein therapeutics beyond traditional mAbs including alternative non-Ig scaffolds, multi-specifics, fusion proteins, and ADCs
* Experience utilizing AI/ML to support lead identification and/or lead optimization efforts  #EligibleforERP
*
* Required Skills:

** Antibody Discovery, Antibody Therapeutics, B Cells, Biochemistry, Biologics, Biophysics, Immune Response, People Management, Program Leadership, Structural Biology
** Preferred

Skills:

**…