Sr Associate Scientist - Conjugation Chemistry

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.

Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best‑in‑class medicines to patients around the world.

As a Senior Associate Scientist in the Early Bioprocess Development within Pfizer Vaccine Research and Development, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will join a large team of Scientists focused on conjugation process development for manufacturing carbohydrate-based conjugate vaccines.

Primary duties include supporting the development and optimization of conjugation methods, purification, and analysis of intermediates and glycoconjugates using chemical and chromatographic methods. The individual will become a key contributor towards supporting the early development and scale up of glycoconjugate vaccines. Careful documentation of work and presentation of data is required. All work is to be done in a compliant manner according to SOP guidelines and cGMP/GLP regulations, where applicable.

Support the development, optimization and scale-up of glycoconjugate vaccine process development.

In process analysis of glycoconjugates and intermediates.

Continuously evaluate each process and technique to determine if it is robust, appropriate, and scalable. If an operation has shortcomings or can be improved, propose solution in discussion with other group members to advance objectives.

Collaborate with colleagues within Vaccine Research and Development organization including Early Bioprocess fermentation, purification, analytical and formulation development groups.

Participate in the technology transfer of developed process to clinical manufacturing site, both internally and externally, and provide the technical support as needed.

Fully document laboratory experiments in electronic notebook in a timely and compliant manner and prepare technical reports as needed.

Perform other duties as assigned.

BS degree in Chemistry/Biochemistry or related discipline with 3 to 6 years laboratory experience or MS degree in Chemistry/Organic Chemistry or related discipline with 0 to 4 years of experience.

Strong background in organic chemistry is required.

Knowledge and ability to operate and maintain relevant instruments, resolve technical problems related to instruments, and execution of analytical methods.

Independently analyze and provide conclusions regarding experimental data generated.

Strong verbal and written communication skills are required.

Experience with documentation of laboratory notebook in an electronic format.

Experience in carbohydrate chemistry

Hands on experience with various analytical techniques such as HPLC, MALS, UV-Vis, NMR, and other routine lab instruments.

Proficiency with personal computers including word processing, spreadsheets, PowerPoint, and relevant scientific software

Work…