Vice President, Sales

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026.

Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial.

In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN
1701 and XEN
1720 (targeting Nav
1.7) and XEN
1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

We are seeking a Vice President, Sales to join our team. The Vice President, Sales will lead the design, build, and execution of Xenon’s U.S. commercial sales organization as the company evolves from a clinical stage biopharmaceutical company into a fully integrated commercial enterprise. This individual will play a critical role in shaping national sales strategy, building a high performing field organization, and driving commercial execution across specialty neurology and CNS markets.

As a core member of the commercial leadership team, the Vice President,Sales will define the field structure, hire and develop sales leadership and frontline talent, and establish the systems, processes, and performance expectations needed to scale effectively. This individual will partner closely with Marketing, Market Access, Medical Affairs, Commercial Operations, Legal, and Compliance to ensure a coordinated, compliant, and high impact go to market strategy.

Success in this role will require strong specialty sales leadership, experience building and scaling teams in growth stage environments, and the ability to translate strategy into focused field execution in a competitive and evolving CNS landscape.

This position reports to the Senior Vice President, Sales & Marketing and will be fully remote.

• Develop and execute the U.S. sales strategy in alignment with corporate and commercial objectives
• Partner with executive leadership to shape commercial vision and growth strategy
• Lead sales launch readiness planning, including field deployment strategy, targeting philosophy, training input, incentive plan partnership, and execution readiness
• Define the field structure, talent profile, and leadership expectations for the sales organization
• Build, hire, lead, and develop a high performing national sales organization, including Regional Directors and field representatives
• Establish clear performance metrics, sales goals, and accountability frameworks across the organization
• Establish the culture, leadership standards, and talent bar for the sales organization to support long term performance and…