Senior Scientist, mRNA Design & Platform Innovation

Company Overview

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities.

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Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation “search-and-replace” technology that finds the precise place in the genome to edit and swaps in a corrected copy of DNA — designed to make only the right edit, in the right position, while minimizing unwanted changes elsewhere in the genome. A single Prime Editor can be tuned to correct the individual mutation found in a given patient, giving Prime Editing the potential to address the vast majority of known disease-causing genetic mutations, across many different tissues, organs, and cell types.

We are seeking an exceptionally driven, discovery-minded Senior Scientist to join our Platform Technology & Innovation team. This team sits at the very heart of Prime Medicine's innovation engine, reflecting our commitment to accelerating the next frontier of Prime Editing science. Its mission is to invent, establish, and rapidly implement the platform technologies that will define what new capabilities Prime Editing can achieve, and ultimately, what cures become possible for patients.

Reporting to the VP of Platform Technology & Innovation, the successful candidate will focus primarily on the design and engineering of RNA components for Prime Editing systems, while also applying molecular biology and Prime Editing expertise to other platform-level research challenges. Unlike most industry roles, this position offers a rare combination of deep, inventive science and direct translational impact with purposeful innovation where discoveries made here move rapidly and deliberately into programs working toward patient benefit.

As the portfolio grows, this role is expected to take on additional scope.

This is a hands-on experimental role with a strong cross-functional dimension. The ideal candidate will bring deep expertise in RNA biology and mRNA engineering, a rigorous and creative scientific mindset, and an unwavering commitment to translating breakthrough science into real-world impact. The team is currently focused on extrahepatic delivery to the lung, laying the foundation for expansion into additional tissues and organs.

• Design, construct, and systematically optimize novel mRNA architectures for Prime Editing applications, including UTR sequences, open reading frame design, codon usage, cap structures, poly(A) tail configurations, and RNA secondary structure, individually and in combination, to maximize expression, stability, translational efficiency, and in vivo performance
• Design and execute well-controlled experiments to probe structure-function relationships in Prime Editing system components; generate clean, interpretable data that drives platform design decisions
• Lead discovery efforts for novel therapeutic approaches and platform-level applications enabled by Prime Editing, beyond core mRNA design, partnering with program and platform teams to advance the most promising directions
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