Senior Director of Clinical Science - Lung

Job Description

Senior Director, Clinical Science – Lung is responsible for providing strategic Clinical Science leadership across the lung disease area, with accountability spanning multiple studies, programs, and assets. Reporting to the Executive Director – Lung, Head and Neck, and Gastrointestinal, or to the Head of Clinical Science Oncology, this role contributes to disease area strategy by applying deep therapeutic expertise to guide Clinical Science approaches, support development planning, and promote consistency in scientific standards, medical data review practices, and decision‑making across the portfolio.

The individual in this role is expected to bring deep knowledge of lung cancer, including disease biology, current and emerging treatment landscape, relevant clinical endpoints, and key scientific considerations that influence development strategy and study design. The Senior Director partners closely with Section Heads, Asset Leads, Program Development Team Leads, and cross‑functional development team members to support study planning, data interpretation, issue resolution, and broader program decisions across assigned studies and programs.

This role has a strong strategic orientation and is expected to shape how Clinical Science work is performed across the lung portfolio, including standardization of practices, alignment of scientific approaches, and integration of insights across assets. The Senior Director may have responsibility for direct management and development of multiple Clinical Scientists and is expected to provide leadership, coaching, and clear direction within a matrix environment.

The role requires close collaboration with Clinical Operations, Regulatory Affairs, Biostatistics and Data Management, Drug Safety and Pharmacovigilance, Translational Medicine, Medical Affairs, and other key partner functions, as well as contribution to governance discussions and senior leadership reviews.

Provide strategic Clinical Science leadership across the lung disease area, including multiple studies, programs, and assets. Contribute to disease area strategy by providing Clinical Science input on development opportunities, scientific considerations, portfolio risks, and implications of emerging internal and external data. Partner with Section Heads, Asset Leads, Program Development Team Leads, and cross‑functional leaders to support alignment of Clinical Science activities with broader program and disease area objectives.

Support cross‑study and cross‑asset integration of scientific insights to inform development decisions within the lung portfolio. Standardization and Scientific Consistency Lead efforts to standardize Clinical Science approaches across the lung disease area, including medical data review practices, data interpretation principles, and key deliverables, as appropriate.

Help establish and maintain standards, expectations, and leading practices for Clinical Science work within the lung portfolio. Support alignment across assets on important disease area considerations, including endpoint interpretation, patient population considerations, safety topics, and emerging scientific issues. Advocate for implementation of innovative approaches, including visual analytics, centralized data review, AI‑enabled workflows, and other technologies that improve quality and efficiency.

Provide senior scientific guidance across assigned studies and programs to support high‑quality and consistent Clinical Science input. Guide interpretation of clinical data across studies, cohorts, and assets to support broader understanding of trends, opportunities, risks, and program implications. Support identification and evaluation of important clinical, scientific, and data‑related…