Research Technician III - Lindell Lab & Henrickson Lab

SHIFT:
Day (United States of America)

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This role participates in planned research projects by performing research protocols with minimal direction and guidance from the principal investigator, program director or senior scientists. May exercise moderate discretion and judgement in the execution and interpretation of experiments, and of data derived.

A Research Technician III position is available jointly in the laboratories of Dr. Robert (Brad) Lindell and Dr. Sarah Henrickson at the Children’s Hospital of Philadelphia.

This role is designed for a highly motivated technician interested in human immunobiology at the intersection of critical illness and genetic immune dysregulation, with protected effort and mentorship spanning two complementary but distinct research programs.

Lindell Lab (Sepsis Immunobiology): Dr. Lindell is a pediatric intensivist-scientist studying immune dysregulation, immune recovery, and immunometabolic dysfunction in pediatric sepsis and sepsis-associated multiple organ dysfunction syndrome (MODS). The lab applies high-dimensional immune profiling and systems immunology to samples from prospectively enrolled critically ill children, with the goal of defining targetable immune endotypes and informing precision immunomodulatory strategies.

Henrickson Lab (Inborn Errors of Immunity): Dr. Henrickson’s laboratory focuses on inborn errors of immunity (IEIs) and primary immune regulatory disorders, particularly diseases involving JAK/STAT pathway dysregulation. This work integrates patient-derived samples, advanced cellular immunophenotyping, functional assays, and multi-omic approaches to understand shared mechanisms of immune dysfunction across rare genetic disorders.

Together, these programs create a unique training environment bridging acquired immune dysfunction in critical illness and genetically mediated immune dysregulation, with strong conceptual and technical overlap.

• Independently perform complex immunological assays using fresh and cryopreserved human biospecimens
• Conduct high-dimensional spectral flow cytometry–based phenotyping and functional assays
• Support multi-omic workflows, including transcriptomic and proteomic sample preparation
• Maintain rigorous experimental documentation, sample tracking, and quality control
• Work collaboratively across both laboratories while receiving direct mentorship from both PIs
• Contribute to project planning, data interpretation, and scientific manuscripts, depending on experience and interest
• Performs research procedures on experimental samples with minimal supervision
• Formulates and performs complex lab experiments and analyzes/report the data
• Performs tasks that require knowledge of advanced techniques and lab equipment
• Performs advanced calculations and maintains appropriate log and lab notebooks
• Assists with planning specific research protocols and procedures
• Assists in development & troubleshooting of new techniques and ideas
• May be required to modify scientific methods and protocols (in conjunction with PI)
• Checks others’ results for completeness and accuracy
• May be responsible for training and mentoring new staff
• May assist in the preparation of grants, journal articles, posters and oral presentations
• May perform routine and non‑routine tests / experiments…